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Bioluminescent Tumor Cell Lines

 
Product   Principle   Data   Literature   Price/Order   Message
 

Cell Lines Available: (Click for pricing and catalogue numbers)

 

Luciferase Stably Expression HeLa Cell Line (Non-Profit) SL-0102-NP
Luciferase Stably Expressing HeLa Cell Line (Profit) SL-0102-FP
Luciferase Stably Expressing HEK293 Cell Line (Non-Profit) SL-0103-NP
Luciferase Stably Expressing HEK293 Cell Line (For-Profit) SL-0103-FP
Luciferase Stably Expressing Jurkat Cell Line (For-Profit) SL-0036-FP
Luciferase Stably Expressing Jurkat Cell Line (Non-Profit) SL-0036-NP
Luciferase Stably Expressing NIH/3T3 Cell Line (For-Profit) SL-0045-FP
Luciferase Stably Expressing NIH/3T3 Cell Line (Non-Profit) SL-0045-NP
Luciferase Stably Expressing A549 Cell Line (For-Profit) SL-0104-FP
Luciferase Stably Expressing A549 Cell Line (Non-Profit) SL-0104-NP
Luciferase Stably Expressing HepG2 Cell Line (For-Profit) SL-0105-FP
Luciferase Stably Expressing HepG2 Cell Line (Non-Profit) SL-0105-NP
Luciferase Stably Expressing K562 Cell Line (For-Profit) SL-0106-FP
Luciferase Stably Expressing K562 Cell Line (Non-Profit) SL-0106-NP

 

Bioluminescent tumor cell lines are critical to cancer investigation, especially imaging of tumors in xenografted animals.  They are used for assessing dissemination of tumor cells in the body of xenografted mice as well as tumor growth or regression under treatment.  Although various types of reporter genes encoding fluorescent proteins have been reported, stable expression of exogenous luciferase in tumor cells combined to systemic injection of luciferin provides an excellent signal/background ratio for external optical imaging.  Signosis has generated a number of luciferase-positive tumor cell lines representative of multiple tumor phenotypes, facilitating evaluation of novel therapeutic modalities.

In addition, bioluminescent tumor cell lines can be used to develop a luciferase activity-based assay, as a positive control for luciferase activity, or to test if experimental conditions affect luciferase expression

 

Benefits:
  • Consistent - Exogenous gene is stably integrated into the genome to avoid experimental/cell-to-cell variations.
  • Time saving - Cell line can be used for experiments right away to study different signaling pathways.