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Human Cytokine ELISA Kits

 
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Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers

 

Human Adiponectin ELISA EA-0201


Adiponectin, also called GBP-28, apM1, AdipoQ and Acrp30, is an adipose tissue-specific protein that circulates in human plasma at high levels. Plasma levels of adiponectin has been reported to be significantly reduced in obese/diabetic mice and humans. It is also decreased in patients with cardiovascular diseases, hypertension or metabolic syndrome. On the contrary, a number of other human diseases such as chronic renal failure, type 1 diabetes and anorexia nervosa are associated with increased plasma adiponectin levels. Plasma adiponectin correlates negatively with glucose, insulin, triglyceride levels and body mass index, and positively with high-density lipoprotein-cholesterol levels and insulin-stimulated glucose disposal.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human EGF ELISA EA-0403


Epidermal growth factor (EGF) is a strong mitogen for many cells, such as fibroblasts. EGF also stimulates the proliferation of embryonic cells. The proliferation of some cell lines has been shown to be inhibited by EGF. EGF acts as a differentiation factor for some cell types. To a limited extent EGF also augments angiogenesis because it is mitogenic for endothelial cells. The mitogenic activity of EGF for endothelial cells can be potentiated by thrombin. EGF is a strong chemoattractant for fibroblasts and epithelial cells. EGF alone and also in combination with other cytokines is an important factor mediating wound healing processes.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human Eotaxin-3 ELISA EA-0512


Eotaxin-3, now also called chemokine (C-C motif) ligand 26 (CCL26) or macrophage inflammatory protein 4-alpha (MIP-4-alpha), is a cytokine belonging to the CC chemokine family. It attracts and activates eosinophils, basophils, and Th2 type T lymphocytes. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human FGFb ELISA EA-0402


Fibroblast growth factor (FGF)-2, also known as basic FGF (FGFb), is a powerful stimulator of angiogenesis in vivo, in addition to being a pleiotropic regulator of the proliferation, migration, differentiation, and survival of many cell types in vitro, including endothelial cells, smooth muscle cells, and pericytes. It is capable of inducing an angiogenic response both in vivo and in vitro. Both basic and acidic FGFs, a heparin-binding family of structurally related cytokines, are widely expressed during embryonic development and normal wound healing, as well as in such angioproliferative diseases as cancer and diabetes.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human G-CSF ELISA EA-0501


Granulocyte colony-stimulating factor (G-CSF) is a colony-stimulating factor hormone. It is produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells and to stimulate the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils, as well as monocytes. G-CSF influences monocyte functions in an anti-inflammatory way. The stimulation of monocytes with G-CSF results in an attenuation of LPS-induced release of IL-1, TNF-a, IL-12 and IL-18.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human GM-CSF ELISA EA-0502


Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. It functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exit the circulation and migrate into tissue, where they mature into macrophages. It has recently showed that GM-CSF plays a key role in inflammatory and autoimmune diseases.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human ICAM-1 ELISA EA-0518


ICAM-1 (Intercellular Adhesion Molecule-1) is a transmembrane glycoprotein primary expressed in immune and endothelial cells.  This typical low level expression of this protein is greatly increased by cytokine stimulation.  The traditional role of ICAM-1 is to stabilize intercellular adhesion; however ICAM-1 can also bind various immune-associated ligands, is the receptor for rhinovirus, and is believed to have a role in proinflammatory signal transduction.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IFNy ELISA EA-0507


Interferons (IFNs) are potent extracellular protein mediators of host defence and homoeostasis. They are cytokines produced by the cells of the immune system in response to challenges by foreign agents such as viruses, parasites and tumor cells. It is produced by a wide variety of cells in response to the presence of double-stranded RNA, a key indicator of viral infection. IFNs are divided into two major subgroups. Type I IFNs all bind to a type I IFN receptor, such as IFN-a and IFN-ß. IFN-y is the sole type II IFN, which binds to a distinct type II receptor. Almost all cell types produce type I IFNs, while the type II IFN-y is produced in T cells and natural killer (NK) cells upon immunological stimulation. IFN-y coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. Cellular effects of IFN-y includes up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IGF-1 ELISA EA-0204


Insulin-like growth factor-I (IGF-I) acts as an important mediator between growth hormone and growth throughout fetal and childhood development. More circumstantial evidence indicates the association of IGF-I to the risk of cancer. High concentrations of IGF-I has been shown to be an increased risk of colorectal cancer and breast cancer in some studies and less consistently with prostate, thyroid, and haematological malignancies. IGF-I is a potent mitogen and important stimulus for adipocyte differentiation. IGF-I can reduce hyperglycemia in patients with severe insulin resistance by direct effects mediated via the IGF-I receptor. IGF-I infusion lowers insulin and lipid levels in healthy humans and reduces plasma leptin concentrations in rats, suggesting that IGF-I may reduce the degree of insulin resistance in type 2 diabetes, obesity, and hyperlipidemia.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-1a ELISA EA-0503


IL-1a and IL-1ß are prominent agonists mediating inflammatory and immunomodulatory effects. Both are produced by macrophages, monocytes and dendritic cells. They are important part of the inflammatory response against infection. They increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes to sites of infection. IL-1a is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by many cell types but is only secreted by monocytes and macrophages.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-1b ELISA EA-0531


IL-1α and IL-1ß are prominent agonists mediating inflammatory and immunomodulatory effects. Both are produced by macrophages, monocytes and dendritic cells. They are important part of the inflammatory response against infection. They increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes to sites of infection. Increased production of IL-1β can lead to a number of autoinflammatory syndromes.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-1RA ELISA EA-0517


IL-1RA (Interleukin-1 Receptor Antagonist) is a member of the interleukin-1 family of cytokines.  It non-productively binds the IL-1 receptor thereby modulating the pro-inflammatory effects of IL-1α and IL-1β.  Mutations in IL-1RA have been linked to osteoporotic fractures, gastric cancer, schizophrenia, and the rare disease Deficiency of the Interleukin-1–Receptor Antagonist (DIRA).  Recombinant IL-1RA is currently used to treat autoimmune disorders and lymphomas.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-2 ELISA EA-0508


Interleukin-2 (IL-2) is a cytokine that plays roles in responding to microbial infection. It is produced primarily by activated T cells. IL-2 mediates its effects by binding to its receptors expressed by T cells, B cells, NK cells, and APCs. The interaction between IL-2 and IL-2R leads to stimulation of the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells. In systemic lupus erythematosus (SLE), IL-2 production by T lymphocytes in vitro is impaired.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-4 ELISA EA-0509


Interleukin-4 (IL-4) is a cytokine that that plays many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 binds to a cell surface receptor complex that consists of the IL-4 binding protein (IL-4R alpha) and the gamma chain of the IL-2 receptor complex (gamma c).


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-6 ELISA EA-0206


Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation. Deregulation of IL-6 production is implicated in the pathology of several disease processes. Its levels are observed in several diseases, including rheumatoid arthritis (RA). IL-6 plays roles in both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response. In addition, like TNFa, IL-6 is another adipocyte secretory product that may be involved in insulin resistance. IL-6 is a cytokine secreted by many cells, including adipocytes and adipose stromal cells. IL-6 secretion is increased in the adipocytes of obese subjects and may be important either as a circulating hormone or as a local regulator of insulin action. IL-6 has been implicated in the development of insulin resistance and type 2 diabetes in obese individuals. Like TNF, IL-6 inhibits the expression of LPL, but, unlike TNF, IL-6 does not stimulate lipolysis.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-8 ELISA EA-0504


Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. IL-8 targets a relative wide range of cells such as endothelial cells, macrophages, mast cells, keratinocytes, but neutrophil granulocytes are the primary target cells. IL-8 is one of the major mediators of the inflammatory response by attracting neutrophils at the site of inflammation.. This chemokine is also a potent angiogenic factor.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-10 ELISA EA-0513


Interleukin-10(IL-10) is a cytokine primarily produced by monocytes and lymphocytes with important immunoregulatory functions.   IL-10 can inhibit the synthesis of many pro-inflammatory cytokines including TNF-α, IL-6, and IL-1, and increase the transcription of anti-apoptotic genes.  Mutations in IL-10 are associated with increased susceptibility to infection and rheumatoid arthritis.  Understanding the conditions that alter the expression of this vital cellular messenger is important for unraveling the mechanisms of these and other diseases and for developing therapeutics


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-12 ELISA EA-0510


Interleukin 12 (IL-12) is an interleukin that plays important roles in the activities of natural killer cells and T lymphocytes, the differentiation of naive T cells into Th1 cells, the growth and function of T cells, the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-a) from T and natural killer (NK) cells, and IL-4 mediated suppression of IFN-γ. It also plays a role in anti-angiogenic activity by increasing production of IFN-γ, which in turn increases the production of IP-10. IL-12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells in response to antigenic stimulation.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-13 ELISA EA-0511


Interleukin 13 (IL-13) is a cytokine that is an important mediator of allergic inflammation and disease. IL-13 is also important in allergic inflammation in many tissues. In addition, it plays functions in anti-inflammation. It is secreted by many cell types, but especially T helper type 2 (Th2) cells.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-15 ELISA EA-0516


IL-15 is a pleiotropic cytokine that is important for both innate and adaptive immune cell homeostasis, as well as peripheral immune function. It plays an important role in the development and the survival of the NK cell lineage. It also plays a role in peripheral immune functions such as T lymphocyte trafficking, innate immune IFN- γ production, and host defense against infectious pathogens.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IL-17a ELISA EA-0514


Interleukin-17a (IL-17a) is a cytokine primarily produced by activated T cells to regulate local tissue inflammation. IL-17A can induce inflammatory cytokine production through the regulation of NFκB and MAPK family pathways. Elevated levels of IL-17 are associated with several chronic inflammatory diseases, including asthma, rheumatoid arthritis, and multiple sclerosis and has become an important potential target for their treatment.  Understanding the conditions that alter the expression of this vital cellular messenger is important for unraveling the mechanisms of these and other diseases and for developing therapeutics.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human Insulin ELISA EA-0515


Insulin is a vital hormone secreted by the pancreas.  It is best known for its ability to control glucose levels in the blood stream; however it can also affect cellular activities such as DNA replication; protein and lipid synthesis; and the uptake of glucose, amino acids, and potassium.  The severity of diseases related to insulin disruption, such as Diabetes mellitus, demonstrates just how important this molecule is to the body.  The ability to simultaneously and quantifiably compare insulin level in many samples can improve our understanding of a multitude of cellular processes and disorders.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human IP-10 ELISA EA-0505


IFN-gamma-inducible protein (IP-10) is a member of the chemokine family of cytokines and is induced in a variety of cells in response to interferon gamma and lipopolysaccharide. It is secreted by a number of cells including monocytes, endothelial cells and fibroblasts. IP-10 plays several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation. several cell types in response to IFN-γ. IP-10 acts as potent inhibitors of angiogenesis in vivo.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human Leptin ELISA EA-0202


Human leptin is a protein of 167 amino acids that plays a key role in regulating energy intake and energy expenditure, including the regulation (decrease) of appetite and (increase) of metabolism. Leptin is produced by adipose tissue and the level of circulating leptin is directly proportional to the total amount of fat in the body. Once leptin has bound to the Ob-Rb receptor, it activates Stat3, which is phosphorylated and travels to the nucleus where it mediates gene expression. One of the main effects on gene expression is the down-regulation of the expression of endocannabinoids, responsible—among their many other functions—for increasing appetite. There are other intracellular pathways activated by leptin, but less is known about how they function in this system. Although leptin is a circulating signal that reduces appetite, in general, obese people who are resistant to the effects of leptin have an unusually high circulating concentration of leptin, in the same way that people with type 2 diabetes are resistant to the effects of insulin. Leptin is also found to stimulate endothelial cell proliferation and angiogenesis.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human MCP-1 ELISA EA-0408


Monocyte chemotactic protein-1 (MCP-1), also called CCL2, is an inflammatory chemokine that plays important roles in recruiting monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. MCP-1 also involves in obesity and insulin resistance by the induction of an inflammatory response (macrophage infiltration) in fatty tissue. In addition, MPC1 has been found in the joints of people with rheumatoid arthritis where may serve to recruit macrophages and perpetuate the inflammation in the joints.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human MIP-1a ELISA EA-0409


Macrophage Inflammatory Proteins (MIP) is a member of the C-C subfamily of chemokines that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis. There are two major forms, MIP-1a and MIP-1b, in humans. They are major factors produced by macrophages after stimulated with bacterial endotoxins. They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as IL-1, IL-6 and TNFa from fibroblasts and macrophages. In addition to its proinflammatory activities, MIP-1a inhibits the proliferation of hematopoietic stem cells in vitro and in vivo.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human b-NGF ELISA EA-0406


Nerve growth factor (NGF) is a small secreted protein which induces the differentiation and survival of particular target neurons (nerve cells). NGF has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. NGF may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. Beta-NGF (β-NGF) is structurally related to BDNF, NT-3 and NT-4. NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B cell survival.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human PAI-1 ELISA EA-0207


Plasminogen activator inhibitor 1 (PAI-1) is a member of a family of proteins that inhibit plasminogen activators. It is a single-chain glycoprotein with a molecular weight of 47 kDa. PAI-1 is the primary inhibitor of tPA and other plasminogen activators in the blood. PAI-1 is mainly produced by the endothelial cells. PAI-1 is also synthesized by adipose tissue. The production of PAI-1 by adipose tissue that elevates plasma PAI-1 levels was observed in insulin resistant patients. Increased PAI-1 levels have been shown to be associated with a number of atherosclerotic risk factors. Insulin and proinsulin correlate with PAI-1 levels. Patients with insulin resistance syndrome and diabetes mellitus tend to have increased PAI-1 levels. Weight loss and treatment aimed at lowering triglyceride and/or cholesterol levels have also been shown to lower PAI-1 levels.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human PDGF-BB ELISA EA-0404


Platelet-derived growth factor (PDGF) is a growth factor that is important to embryonic development, cell proliferation, and cell migration, particularly, in blood vessel formation (angiogenesis). Like VEGF, PDGF is able to independently initiate angiogenesis and mediate blood vessel growth and behavior. The protein is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). It has been shown that the cis oncogene is derived from the PDGF B-chain gene. It binds to PDGF receptors, which activate signal transduction pathways such as the PI3K pathway, and subsequently regulate downstream gene expression and the cell cycle. PDGF has also been linked to several diseases such as atherosclerosis, fibrosis and malignant diseases.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human PIGF-1 ELISA EA-0405


Placental-derived growth factor (PIGF) is a dimeric glycoprotein showing a high degree of sequence similarity to VEGF. There are two alternative splicing forms of the PIGF primary transcript; PIGF-1 and PIGF-2. It is expressed in a number of tissues, such as thyroid, lung and placenta. PIGF is an angiogenic factor that is able to induce angiogenesis in vivo and stimulate the migration and proliferation of endothelial cells in vitro. Receptors for PlGF include products of the fms-like tyrosine kinase (flt-1).


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human Rantes ELISA EA-0506


RANTES is a chemotactic protein for T cells, eosinophils, and basophils. RANTES is produced by circulating T-cells. The synthesis of RANTES is induced by TNF-alpha and IL1-alpha. It plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, Rantes also induces the proliferation and activation of certain natural-killer (NK) cells to form CC-Chemokine-activated killer cells. It is also an HIV-suppressive factor released from CD8+ T cells. RANTES increases the adherence of monocytes to endothelial cells.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human Resistin ELISA EA-0205


Adipocytokines are a group of diverse effector molecules that are produced by adipose cells. Abnormal expression of adipokines such as Resistin is associated with the development of insulin resistance, diabetes and other metabolic and cardiovascular disorders in man. Mouse Resistin was described as a novel obesity-mediated adipocytokine that impairs glucose homeostasis by affecting both insulin-stimulated glucose uptake in adipose tissue and hepatic glucose production during fasting. However, there were initially two opposite views on human Resistin. Some studies have shown the ccorrelations between Resistin and obesity. Serum Resistin levels increase with increased adiposity and conversely, decline with decreased adiposity following medical treatment. However, other studies presented contradictory evidences that significantly decreased serum concentrations of resistin with increased adiposity. Resistin has also been shown to increase the expression of several pro-inflammatory cytokines including IL-1, IL-6, IL-12, and TNF-a via NF-kB.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers




Human SCF ELISA EA-0407


Stem cell factor (SCF) is a growth factor for multiple cell types. It is expressed in glioma cells and as a result of various types of brain injury. Tumor-induced brain injury, brain cell-mediated SCF expression contributes to tumor growth by setting up an environment that supports angiogenesis and tumor progression. SCF expression is not directly linked to tumor cell proliferation but instead encourages the growth of blood vessels needed to support the expanding tumor.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


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Human TGF-ß1 ELISA EA-0208


The transforming growth factor beta 1 (TGF-ß1) gene codes a multifunctional cytokine that controls proliferation, differentiation, and other functions in many cell types, including cancer cells, the surrounding stromal cells, immune cells, endothelial and smooth-muscle cells. It causes immunosuppression and angiogenesis, which makes the cancer more invasive. TGF-ß also converts effector T-cells, which normally attack cancer with an inflammatory (immune) reaction, into regulatory (suppressor) T-cells, which turn off the inflammatory reaction. TGF-ß induces apoptosis in numerous cell types. TGF-ß can act on adipocyte precursor cells. TGF- ß1 has been shown to be a potent inhibitor of the differentiation of adipogenic cell lines. In addition, a differentiation-defective, insulin-independent cell line derived from the adipogenic cell line 1246 produces in its conditional medium a TGF- ß1-like polypeptide which could modulate the cell ability to differentiate in an autocrine fashion. Increased TGF-b1 expression was associated with BMI and abdominal adipose tissue in morbid obesity.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


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Human TNF-a ELISA EA-0203


Tumour Necrosis Factor alpha (TNFa), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. The protein is also important for angiogenesis that is critical to the growth, progression, and metastasis of solid tumors. Furthermore, TNFa is associated with obesity. It is chronically elevated in adipose tissues of obese rodents and humans and may represent an important link between obesity and insulin resistance. In both obese mice and humans, TNFa is overexpressed in adipose tissue. TNFa inhibits insulin signaling, at least in part by blocking insulin receptor tyrosine kinase activity and inducing serine phosphorylation of insulin receptor substrate-1 (IRS-1). However, it is unclear what the physiological stimulator of TNF-a production by adipocyte during obesity is and how IRS-1 inhibits the tyrosine kinase activity of the insulin receptor after TNF-a treatment of the cells. A better understanding of the connection(s) between the TNF-a and the insulin signaling pathways could be important to find a cure for the state of insulin resistance observed during obesity.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


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Human VCAM-1 ELISA EA-0519


VCAM-1 (Vascular Cell Adhesion Molecule-1) is a transmembrane glycoprotein, which is expressed in a variety of cells including fibroblasts, macrophages, endothelial cells, smooth muscle cells, and neurons.  In endothelial cells, VCAM-1 is only expressed after cytokine stimulation.  The primary roles of VCAM-1 include mediation of leukocyte-endothelial cell adhesion and signal transduction.  VCAM-1 has been implicated in atherosclerosis and rheumatoid arthritis. 


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


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Human VEGF ELISA EA-0401


Vascular endothelial growth factor (VEGF) is one of the most potent and specific tumor-angiogenic factors. VEGF is used by oxygen-hungry cells to promote growth of blood vessels. It binds to specialized receptors on the surfaces of endothelial cells and induces to build new vessels. Most tumors produce VEGF and inhibition of VEGF-induced angiogenesis significantly inhibits tumor growth in vivo. A number of antiangiogenic drugs have shown to be capable of decreasing the number of vessels. VEGF expression correlates with microvessel density in a number of solid malignancies including carcinomas of the breast, lung, prostate, and colon.


Benefits:
 

  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.
  • Specific - A pair of highly selective antibodies against specific cytokine.
  • Simple procedure - All in one system with a pre-coated 96-well plate.


Click Here for Price Information and Catalogue Numbers