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Mouse Cytokine ELISA Kits

 
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 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.
 

Mouse EGF ELISA EA-2403


Epidermal growth factor (EGF) is a strong mitogen for many cells, such as fibroblasts. EGF also stimulates the proliferation of embryonic cells.  The proliferation of some cell lines has been shown to be inhibited by EGF. EGF acts as a differentiation factor for some cell types. To a limited extent EGF also augments angiogenesis because it is mitogenic for endothelial cells. The mitogenic activity of EGF for endothelial cells can be potentiated by thrombin.  EGF is a strong chemoattractant for fibroblasts and epithelial cells. EGF alone and also in combination with other cytokines is an important factor mediating wound healing processes.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse FGFb ELISA EA-2202


Fibroblast growth factor (FGF)-2, also known as basic FGF (FGFb), is a powerful stimulator of angiogenesis in vivo, in addition to being a pleiotropic regulator of the proliferation, migration, differentiation, and survival of many cell types in vitro, including endothelial cells, smooth muscle cells, and pericytes.  It is capable of inducing an angiogenic response both in vivo and in vitro. Both basic and acidic FGFs, a heparin-binding family of structurally related cytokines, are widely expressed during embryonic development and normal wound healing, as well as in such angioproliferative diseases as cancer and diabetes.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse GCSF ELISA EA-2501


Granulocyte colony-stimulating factor (G-CSF) is a colony-stimulating factor hormone. It is produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells and to stimulate the bone marrow to release them into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils, as well as monocytes.  G-CSF influences monocyte functions in an anti-inflammatory way.  The stimulation of monocytes with G-CSF results in an attenuation of LPS-induced release of IL-1, TNF-a, IL-12 and IL-18.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse GM-CSF ELISA EA-2502


Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts.  It functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.  Monocytes exit the circulation and migrate into tissue, where they mature into macrophages.  It has recently showed that GM-CSF plays a key role in inflammatory and autoimmune diseases.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IFNy ELISA EA-2404


Interferons (IFNs) are potent extracellular protein mediators of host defence and homoeostasis. They are cytokines produced by the cells of the immune system in response to challenges by foreign agents such as viruses, parasites and tumor cells. It is produced by a wide variety of cells in response to the presence of double-stranded RNA, a key indicator of viral infection. IFNs are divided into two major subgroups. Type I IFNs all bind to a type I IFN receptor, such as IFN-a and IFN-ß.  IFN-y is the sole type II IFN, which binds to a distinct type II receptor. Almost all cell types produce type I IFNs, while the type II IFN-y is produced in T cells and natural killer (NK) cells upon immunological stimulation. IFN-y coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. Cellular effects of IFN-y includes up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IGF-1 ELISA EA-2204


Insulin-like growth factor-I (IGF-I) acts as an important mediator between growth hormone and growth throughout fetal and childhood development. More circumstantial evidence indicates the association of IGF-I to the risk of cancer. High concentrations of IGF-I has been shown to be an increased risk of colorectal cancer and breast cancer in some studies and less consistently with prostate, thyroid, and haematological malignancies.  IGF-I is a potent mitogen and important stimulus for adipocyte differentiation. IGF-I can reduce hyperglycemia in patients with severe insulin resistance by direct effects mediated via the IGF-I receptor. IGF-I infusion lowers insulin and lipid levels in healthy humans and reduces plasma leptin concentrations in rats, suggesting that IGF-I may reduce the degree of insulin resistance in type 2 diabetes, obesity, and hyperlipidemia.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-1a ELISA EA-2503


IL-1a and IL-1ß are prominent agonists mediating inflammatory and immunomodulatory effects.  Both are produced by macrophages, monocytes and dendritic cells. They are important part of the inflammatory response against infection. They increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes to sites of infection.  IL-1a is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by many cell types but is only secreted by monocytes and macrophages.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-1b ELISA EA-2508


IL-1a and IL-1ß are prominent agonists mediating inflammatory and immunomodulatory effects.  Both are produced by macrophages, monocytes and dendritic cells. They are important part of the inflammatory response against infection. They increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes to sites of infection.  IL-1ß production in peripheral tissue has also been associated with hyperalgesia (increased sensitivity to pain) associated with fever.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-2 ELISA EA-2509


Interleukin-2 (IL-2) is a cytokine that plays roles in responding to microbial infection. It is produced primarily by activated T cells. IL-2 mediates its effects by binding to its receptors expressed by T cells, B cells, NK cells, and APCs. The interaction between IL-2 and IL-2R leads to stimulation of the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells. In systemic lupus erythematosus (SLE), IL-2 production by T lymphocytes in vitro is impaired.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-4 ELISA EA-2510


Interleukin-4 (IL-4) is a cytokine that that plays many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 binds to a cell surface receptor complex that consists of the IL-4 binding protein (IL-4R alpha) and the gamma chain of the IL-2 receptor complex (gamma c).

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-5 ELISA EA-2511


IL-5 is a protein that produced by T-cells. It regulates the activation of eosinophils, and promotes the production of cytotoxic lymphocytes. It also acts as a differentiation and proliferation factor for B-cells. The elevated generation of this cytokine has been reported to be related to asthma or hypereosinophilic syndromes.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-6 ELISA EA-2206


Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation. Deregulation of IL-6 production is implicated in the pathology of several disease processes.  Its levels are observed in several diseases, including rheumatoid arthritis (RA).  IL-6 plays roles in both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response.  In addition, like TNFa, IL-6 is another adipocyte secretory product that may be involved in insulin resistance.  IL-6 is a cytokine secreted by many cells, including adipocytes and adipose stromal cells.  IL-6 secretion is increased in the adipocytes of obese subjects and may be important either as a circulating hormone or as a local regulator of insulin action. IL-6 has been implicated in the development of insulin resistance and type 2 diabetes in obese individuals. Like TNF, IL-6 inhibits the expression of LPL, but, unlike TNF, IL-6 does not stimulate lipolysis.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-10 ELISA EA-2513


Interleukin-10 (IL-10) is a cytokine primarily produced by monocytes and lymphocytes with important immunoregulatory functions.   IL-10 can inhibit the synthesis of many pro-inflammatory cytokines including TNF-α, IL-6, and IL-1, and increase the transcription of anti-apoptotic genes.  Mutations in IL-10 are associated with increased susceptibility to infection and rheumatoid arthritis.  Understanding the conditions that alter the expression of this vital cellular messenger is important for unraveling the mechanisms of these and other diseases and for developing therapeutics

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-12 ELISA EA-2514


Interleukin 12 (IL-12) is an interleukin that plays important roles in the activities of natural killer cells and T lymphocytes, the differentiation of naive T cells into Th1 cells, the growth and function of T cells, the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-a) from T and natural killer (NK) cells, and IL-4 mediated suppression of IFN-γ. It also plays a role in anti-angiogenic activity by increasing production of IFN-?, which in turn increases the production of IP-10. IL-12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells in response to antigenic stimulation.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-15 ELISA EA-2515


IL-15 is a pleiotropic cytokine that is important for both innate and adaptive immune cell homeostasis, as well as peripheral immune function. It plays an important role in the development and the survival of the NK cell lineage. It also plays a role in peripheral immune functions such as T lymphocyte trafficking, innate immune IFN- γ production, and host defense against infectious pathogens.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-17a ELISA EA-2516


Interleukin-17a (IL-17a) is a cytokine primarily produced by activated T cells to regulate local tissue inflammation. IL-17a can induce inflammatory cytokine production through the regulation of NFκB and MAPK family pathways. Elevated levels of IL-17 are associated with several chronic inflammatory diseases, including asthma, rheumatoid arthritis, and multiple sclerosis and has become an important potential target for their treatment.  Understanding the conditions that alter the expression of this vital cellular messenger is important for unraveling the mechanisms of these and other diseases and for developing therapeutics.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse IL-23 ELISA EA-2517


The cytokine Interleukin-23 (IL-23) is a heterodimer comprised of a p19 Interleukin-23 subunit and a p40 subunit of IL-12.  The complete IL-23 is produced in activated macrophages and dendritic cells.  IL-23 acts on memory T cells to induce proliferation and IFNy and IL-17 production.  IL-23 is known to play a role in multiple sclerosis, inflammatory bowel disease, and psoriasis.  In fact, a monoclonal antibody that recognizes IL-23 and IL-12 is approved to treat psoriasis and psoriatic arthritis.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse Leptin ELISA EA-2202


Mouse leptin plays a key role in regulating energy intake and energy expenditure, including the regulation (decrease) of appetite and (increase) of metabolism.  Leptin is produced by adipose tissue and the level of circulating leptin is directly proportional to the total amount of fat in the body. Once leptin has bound to the Ob-Rb receptor, it activates Stat3, which is phosphorylated and travels to the nucleus where it mediates gene expression. One of the main effects on gene expression is the down-regulation of the expression of endocannabinoids, responsible—among their many other functions—for increasing appetite. There are other intracellular pathways activated by leptin, but less is known about how they function in this system. Although leptin is a circulating signal that reduces appetite, in general, obese people who are resistant to the effects of leptin have an unusually high circulating concentration of leptin, in the same way that people with type 2 diabetes are resistant to the effects of insulin.  Leptin is also found to stimulate endothelial cell proliferation and angiogenesis.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse MCP-1 ELISA EA-2408


Monocyte chemotactic protein-1 (MCP-1), also called CCL2, is an inflammatory chemokine that plays important roles in recruiting monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. MCP-1 also involves in obesity and insulin resistance by the induction of an inflammatory response (macrophage infiltration) in fatty tissue.  In addition, MPC1 has been found in the joints of people with rheumatoid arthritis where may serve to recruit macrophages and perpetuate the inflammation in the joints.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse MIP-1a ELISA EA-2409


Macrophage Inflammatory Protein-1 (MIP-1) is a member of the C-C subfamily of chemokines that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis.  MIP-1 is a major factor produced by macrophages after stimulated with bacterial endotoxins. It activates granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. It also induces the synthesis and release of other pro-inflammatory cytokines such as IL-1, IL-6 and TNFa from fibroblasts and macrophages.  In addition to its proinflammatory activities, MIP-1 inhibits the proliferation of hematopoietic stem cells in vitro and in vivo.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse b-NGF ELISA EA-2518


Nerve growth factor (NGF) is a small secreted protein which induces the differentiation and survival of particular target neurons (nerve cells). NGF has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. NGF may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. Beta-NGF (β-NGF) is structurally related to BDNF, NT-3 and NT-4. NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B cell survival.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse PDGF-BB ELISA EA-2519


Platelet-derived growth factor (PDGF) is a growth factor that is important to embryonic development, cell proliferation, and cell migration, particularly, in blood vessel formation (angiogenesis). Like VEGF, PDGF is able to independently initiate angiogenesis and mediate blood vessel growth and behavior. The protein is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). It has been shown that the cis oncogene is derived from the PDGF B-chain gene. It binds to PDGF receptors, which activate signal transduction pathways such as the PI3K pathway, and subsequently regulate downstream gene expression and the cell cycle. PDGF has also been linked to several diseases such as atherosclerosis, fibrosis and malignant diseases.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse Rantes ELISA EA-2506


Rantes is a chemotactic protein for T cells, eosinophils, and basophils.  RANTES is produced by circulating T-cells.  The synthesis of RANTES is induced by TNF-alpha and IL1-alpha.  It plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, Rantes also induces the proliferation and activation of certain natural-killer (NK) cells to form CC-Chemokine-activated killer cells.  It is also an HIV-suppressive factor released from CD8+ T cells.  RANTES increases the adherence of monocytes to endothelial cells.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse Resistin ELISA EA-2520


Adipocytokines are a group of diverse effector molecules that are produced by adipose cells. Abnormal expression of adipokines such as Resistin is associated with the development of insulin resistance, diabetes and other metabolic and cardiovascular disorders in man. Mouse Resistin was described as a novel obesity-mediated adipocytokine that impairs glucose homeostasis by affecting both insulin-stimulated glucose uptake in adipose tissue and hepatic glucose production during fasting. However, there were initially two opposite views on human Resistin. Some studies have shown the ccorrelations between Resistin and obesity. Serum Resistin levels increase with increased adiposity and conversely, decline with decreased adiposity following medical treatment. However, other studies presented contradictory evidences that significantly decreased serum concentrations of resistin with increased adiposity. Resistin has also been shown to increase the expression of several pro-inflammatory cytokines including IL-1, IL-6, IL-12, and TNF-a via NF-kB.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse SCF ELISA EA-2407


Stem cell factor (SCF) is a growth factor for multiple cell types.  It is expressed in glioma cells and as a result of various types of brain injury. Tumor-induced brain injury, brain cell-mediated SCF expression contributes to tumor growth by setting up an environment that supports angiogenesis and tumor progression.  SCF expression is not directly linked to tumor cell proliferation but instead encourages the growth of blood vessels needed to support the expanding tumor.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse TGF-ß1 ELISA EA-2521


The transforming growth factor beta 1 (TGF-ß1) gene codes a multifunctional cytokine that controls proliferation, differentiation, and other functions in many cell types, including cancer cells, the surrounding stromal cells, immune cells, endothelial and smooth-muscle cells. It causes immunosuppression and angiogenesis, which makes the cancer more invasive. TGF-ß also converts effector T-cells, which normally attack cancer with an inflammatory (immune) reaction, into regulatory (suppressor) T-cells, which turn off the inflammatory reaction. TGF-ß induces apoptosis in numerous cell types. TGF-ß can act on adipocyte precursor cells. TGF- ß1 has been shown to be a potent inhibitor of the differentiation of adipogenic cell lines. In addition, a differentiation-defective, insulin-independent cell line derived from the adipogenic cell line 1246 produces in its conditional medium a TGF- ß1-like polypeptide which could modulate the cell ability to differentiate in an autocrine fashion. Increased TGF-b1 expression was associated with BMI and abdominal adipose tissue in morbid obesity.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse TNFa ELISA EA-2203


Tumour Necrosis Factor alpha (TNFa), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. The protein is also important for angiogenesis that is critical to the growth, progression, and metastasis of solid tumors.  Furthermore, TNFa is associated with obesity.  It is chronically elevated in adipose tissues of obese rodents and humans and may represent an important link between obesity and insulin resistance.  In both obese mice and humans, TNFa is overexpressed in adipose tissue.  TNFa inhibits insulin signaling, at least in part by blocking insulin receptor tyrosine kinase activity and inducing serine phosphorylation of insulin receptor substrate-1 (IRS-1). However, it is unclear what the physiological stimulator of TNF-a production by adipocyte during obesity is and how IRS-1 inhibits the tyrosine kinase activity of the insulin receptor after TNF-a treatment of the cells. A better understanding of the connection(s) between the TNF-a and the insulin signaling pathways could be important to find a cure for the state of insulin resistance observed during obesity.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.



Mouse VEGF ELISA EA-2401


Vascular endothelial growth factor (VEGF) is one of the most potent and specific tumor-angiogenic factors. VEGF is used by oxygen-hungry cells to promote growth of blood vessels. It binds to specialized receptors on the surfaces of endothelial cells and induces to build new vessels. Most tumors produce VEGF and inhibition of VEGF-induced angiogenesis significantly inhibits tumor growth in vivo. A number of antiangiogenic drugs have shown to be capable of decreasing the number of vessels.  VEGF expression correlates with microvessel density in a number of solid malignancies including carcinomas of the breast, lung, prostate, and colon.

 
 Benefits:
  • Cost-effective analysis - High Quality with the most competitive price.
  • Efficient and flexible - Multiple samples can be analyzed simultaneously.

  • Specific - A pair of highly selective antibodies are against specific cytokine. 
  • Simple procedure - All in one system with a pre-coated 96-well plate.