Positive Inducers for Reporter Stable Cell Line

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Gene function analysis, target discovery and validation, assay development, and compound screening often need cell-based assays.  Stable cell lines that are engineered to express a gene of interest via transgene integrations into the host genome provide an efficient approach to conduct such analysis.  At Signosis, we help researchers save time and labor in generating and validating stable cell lines so scientists can spend more effort on solving the big questions.  We offer a wide-selection of validated luciferase reporter cell lines that measure transcription factor activity as a read-out for various signaling pathways.  Click on the transcription factors listed below to learn more.


Transcription Factors Chemical or protein inducer
Cell Lines Available
  • NFkB
TNFa or IL-1a Hela, NIH/3T3, HEK293, A549, HepG2, MCF-7
  • NFAT
PMA and Ionomycin Hela
  • p53
Doxorubicin or quinacrine Hela, RKO
LiCl and Wnt3a HEK293, Hela
  • SMAD
TGFbeta HepG2
  • NRF2
tBHQ or rosiglitazone MCF7
  • STAT1
IFNgamma Hela
  • STAT3
Oncostatin M Hela
  • HIF
DFO or CoCl2 NIH/3T3
  • Estrogen Receptor (ER)
beta-estradiol T47D
  • Androgen Receptor (AR)
Dihydrotestosterone (DHT) MDA-MB-453
  • Glucocorticoid Receptor (GR)
Dexamethasone (DEX) MDA-MB-453, Hela
  • AP-1
PMA Hela
  • CREB
Forskolin HEK293