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Stably Expressing Cell Lines

 
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MMP9 Stably Expressing HEK293 Cell Line


Cell Lines Available: (Click for pricing and catalogue numbers)


MMP9 Stably Expressing HEK293 Cell Line (Non-Profit) EL-1003-NP
MMP9 Stably Expressing HEK293 Cell Line (Profit) EL-1003-FP

 

Matrix metalloproteinase (MMP)-9 is one of the most widely investigated MMPs.  It regulates pathological remodeling processes that occur in inflammation, fibrosis, cardiovascular disease, and cancer.  MMP-9 also plays an increasingly important role in several aspects of central nervous system homeostasis.  Currently, the mechanism of MMP-9 function remains elusive.  Signosis has developed a HEK293 cells stably expressing MMP-9 to facilitate the studies involving MMP-9.

 

Benefits:

  • Broad applications - Stably express multifunctional kinase MMP9 for studying a wide variety of biological areas.
  • Re-transfectable and re-infectable - The cell line is able to transfected and infected with other reporters or genes for functional study.
  • Co-immunoprecipitation - Stably express with DYKDDDDK tag for facilitating protein interaction analysis.
  • Consistent - Exogenous gene is stably integrated into the genome to avoid experimental/cell-to-cell variations.
  • Time saving - Cell line can be used for experiments right away to study different signaling pathways.



GSK3β Stably Expressing Cell Line


Cell Lines Available: (Click for pricing and catalogue numbers)


GSK3β Stably Expressing Hela Cell Line (Non-Profit) EL-1001-NP
GSK3β Stably Expressing Hela Cell Line (Profit) EL-1001-FP
GSK3β Stably Expressing HEK293 Cell Line (Non-Profit) EL-1002-NP
GSK3β Stably Expressing HEK293 Cell Line (Profit) EL-1002-FP

GSK3β  is multifunctional kinase known to be a key regulator of a wide range of cellular functions. GSK3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors regulating the survival or apoptosis. β-Catenin, a  key component in Wnt signaling pathway,  is phosphorylated by GSK3β. Inhibition of GSK3β activity leads to stabilization and accumulation of β-catenin in the cytosol, which is shuttled into the nucleus and regulates gene expression.  Dysregulation of GSK3β expression leads to many pathological conditions, including Alzheimer’s disease, inflammation, diabetes, and cancer. Many studies have supported GSK3β playing a role as a tumor suppressor and tumor promoter.  Signosis provided GSK-3β Stably Expressing HeLa or HEK293 Cell Line for GSK3β signaling pathway study.

 

Benefits:

  •  Broad applications - Stably express multifunctional kinase GSK-3β  for studying Wnt pathway and a wide variety of biological areas.
  • Re-transfectable and re-infectable - The cell line is able to transfected and infected with other reporters or genes for functional study.
  • Co-immunoprecipitation - Stably express with DYKDDDDK tag for facilitating protein interaction analysis.
  • Consistent - Exogenous gene is stably integrated into the genome to avoid experimental/cell-to-cell variations.
  • Time saving - Cell line can be used for experiments right away to study different signaling pathways.



NF-kB (p65) Stably Expressing Cell Line


 Cell Lines Available: (Click for pricing and catalogue numbers)


NF-kB (p65) Stably Expressing Cell Line (Non-Profit) SL-0101-NP
NF-kB (p65) Stably Expressing Cell Line (Profit) SL-0101-FP

 

NF-kB is composed of homo- and heterodimers of five members of the Rel family including NF-kB1(p50), NF-kB2 (p52), RelA (p65), RelB, and c-Rel (Rel). The major dimer, RelA(p65)/p50 is sequestered in the cytosol of unstimulated cells via IKBs. Signal induction leads to IkB dissociation and degradation and allows the activation of the NF-kB complex. The activated NF-kB complex translocates into the nucleus, binds DNA at kB-binding motifs and then initiates the target gene transcription. The NFkB plays an important role in many biological processes, such as differentiation, proliferation and apoptosis, and the dysfunction of NFkB can cause many diseases, such as inflammation and cancer.  Signosis has developed NFkB (p65) Stably Expressing Cos-7 cell line, which allows you to study NFkB pathway effectively.

 

Benefits:
  • Consistent - Exogenous gene is stably integrated into the genome to avoid experimental/cell-to-cell variations.
  • Time saving - Cell line can be used for experiments right away to study different signaling pathways.