Transcriptional regulation plays a critical role in the control of biological processes, and transcription factors have been considered as master switches for cell fate determination. The cancer stem cell paradigm postulates that decontrolled tissue-specific stem cells or progenitor cells are precursors for cancer biogenesis. Cancer stem cells are a subset of cancer cells within a tumor that have stem cell-like characteristics. During tumorigenesis, deregulated transcription factor expression or activation can promote abnormal self-renewal, proliferation, and differentiation of the cells. For example, OCT4, Sox2,KLF4, Myc and Nanog have been shown to possess the power to reprogram somatic cells into pluripotent cells by reactivating pluripotent genes and silencing somatic genes. Understanding the activation patterns of cancer stem cell related transcription factors in a tumor can help to understand the transcriptional mechanism of cancer stem cell and provide better approaches for targeting and eliminating cancer stem cells.
 
FA-1004's data was extracted from our customer, NIH(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003573/).