The Unfolded Protein Response (UPR) is a conserved and essential stress response that cells activate to combat endoplasmic reticulum (ER) stress, commonly caused by the accumulation of misfolded proteins or failing protein quality control.   UPR signaling has been identified as one of the avenues leading to the inflammatory response. The integration of ER stress, oxidative stress and the inflammatory response is critical to the pathogenesis of a variety of diseases, such as  diabetes, Alzheimer�s, Parkinson�s, and obesity.  It has been demonstrated that some cytokines can activate ER Stress and that ER stress can increase the expression of certain cytokines as well.  Therefore, cytokine profiling provides a valuable tool for examining the relationship between cytokine expression and ER stress response.  Signosis� ER stress ELISA Strip allows quantitative profiling and measures 8 ER stress-associated cytokines. The list of cytokines is as follows: TNF?, IL-1?,IFN?, IL-6 ,IGF-1, MCP-1, Leptin and TGF? .