The peroxisome-proliferator activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily of transcription factors. PPARgamma is important to a variety of biological processes, such as adipocyte differentiation, glucose homeostasis, lipid trafficking as well as vascular function and hypertension. PPARgamma exerts its effects by regulating target gene transcription in a ligand-dependent manner. Upon activation, the PPARgamma-RXR heterodimer binds to specific DNA sequences on the target gene promoter and leads to transcriptional regulation.
Signosis has developed a plate-based array for profiling 20+ PPARgamma-regulated genes. By using this assay, researchers are able to compare gene expression in up to three samples on a single microtiter plate.