The hIL11RA/hIL6ST-STAT3 Luciferase Reporter HEK293 Cell Line is a stable, ready-to-use reporter system engineered to monitor IL-11–mediated signaling through the JAK/STAT3 pathway.
This cell line co-expresses human IL-11 receptor alpha (IL-11RA, Ref Seq: NM_004512.3) and IL-6 signal transducer (IL-6ST/gp130, Ref Seq: NM_002184.3), enabling robust and specific responsiveness to IL-11 stimulation. Activation of the receptor complex leads to downstream STAT3 signaling, which is quantitatively measured via a luciferase reporter under the control of STAT3-responsive elements.
Designed for high sensitivity and reproducibility, this cell line provides a convenient platform for evaluating IL-11 pathway activation, screening agonists or antagonists, and studying cytokine-driven STAT3 signaling. The stable integration of receptor components and reporter construct ensures consistent performance across assays, making it well suited for both routine testing and high-throughput applications.
Key Features:
Stable expression of human IL-11RA and IL-6ST (gp130)
STAT3-responsive luciferase reporter for sensitive signal detection
Specific response to IL-11–induced pathway activation