Serum response factor (SRF) is a transcription factor that regulates genes involved in cell growth, differentiation, cytoskeletal organization, and smooth muscle contraction. The SRF luciferase reporter vector is designed to study the transcriptional activity of SRF. The vector contains an SRF DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report SRF activity while maintaining a low basal level of transcription.
 
The inclusion of a neomycin resistance gene in the vector allows it to be used for stable cell line selection. In addition, the vector also has a GFP-tag which can be used to monitor transfection efficiency. A map of the vector can be found in the product's image gallery.