top of page

Lentiviral RTK Expression Vectors

Comprehensive Systems for Signal Transduction, Oncology, and Drug Screening

Signosis offers a diverse collection of fully sequenced lentiviral Receptor Tyrosine Kinase (RTK) expression vectors designed for high-efficiency transduction across a wide array of cell lines.

 

Because traditional transfection methods often fall short in primary cells, suspension lines, or hard-to-transfect targets, our lentiviral delivery platforms ensure robust, long-term, and stable expression of key RTK families. Whether you are investigating normal signal transduction pathways or modeling cancer-driving mutations and acquired drug resistance, our vectors provide a reliable foundation for your assays.

Plenti RTK Expression vector map.png

Advantages of Signosis Lentiviral RTK Expression Vectors

  • Efficiently deliver and express genes of interest in both dividing and non-dividing cells, including primary cells and suspension lines.

  • Contains essential elements (HIV-1 LTRs, packaging signals, WPRE, and cPPT) for enhanced viral titer yields and transcript stability.

  • Strong Promoters: Powered by optimized viral MSCV promoter for high-level expression of your target kinase.

  • Selection & Reporting: Vectors feature fluorescent copGFP reporter markers driven by independent EF-1 promoter, with optional Antibiotic selection of your choice for easy tracking and clean selection including:

    • G418​

    • Puromycin

  • Optional terminal tags (such as FLAG or HA) may be included to simplify protein tracking and Western blot validation.

Major RTK Families Available

Our growing catalog covers critical receptor tyrosine kinase families involved in growth, differentiation, angiogenesis, and oncogenesis:

EGFR

  • Classical-Like Mutations (e.g., L858R, Del19)

  • T790M-like Mutations (e.g., T790M, L792H, C797S)

  • Exon 20 Loop Insertions (e.g., H773_V774insNPH)

  • PACC Mutations (e.g., L718Q)

FLT3

  • Wild-Type Kinase Domain Variants:

    • D835H/F/N/E/V/Y

VEGFR (KDR/FLK-1)

  • Wild-Type and Kinase Domain Variants:

    • VEGFR2 (KDR) WT

    • V916M

    • T925I

ALK

  • Fusions: EML4-ALK (Variants 1, 2, and 3)

  • Resistance Variants:

    • G1202R

    • L1196M

    • I1171T

    • F1174L

ROS1

  • Fusions: CD74-ROS1, EZR-ROS1, SDC4-ROS1

  • Resistance Variants:

    • G2032R

    • D2033N

    • S1986Y

HER2

  • ECD Mutations: S310F

  • Truncated Isoform: p95

  • Kinase Domain Variants:

    • A775_G776insYVMA​

    • P780_Y781insGSP

    • and more

JAK2

  • Wild-Type Kinase Domain Variants:

    • V617F​

    • V617F + EPOR

    • T875N

    • R683G

    • and more

MET

  • Exon 14 Skipping: MET ex14del

  • Kinase Domain Resistance

    • Y1230H/C/S

    • D1228N/H

    • G1163R

RET

  • Fusions: KIF5B-RET, CCDC6-RET

  • Resistance Variants:

    • V804M

    • V804L

    • G810R

    • G810S

Products

Filter Products by RTK
Name
SKU
Formatted Price
plenti-EGFR WT
LVR-0002
$800.00
plenti-EGFR (L858R)
LVR-0003
$800.00
plenti-EGFR (L858R+T790M)
LVR-0004
$800.00
plenti-EGFR (Del19 (Del746-750))
LVR-0005
$800.00
plenti-EGFR (Del19 (Del746-750)+T790M)
LVR-0006
$800.00
plenti-EGFR( D770_N771insSVD )
LVR-0008
$800.00
plenti-EGFR (A763_Y764insFQEA)
LVR-0009
$800.00
plenti-EGFR (A767_dupASV)
LVR-0010
$800.00
plenti-EGFR (Del19 (del747-753InsS))
LVR-0011
$800.00
plenti-EGFR (Del19 (del747-753InsS)+T790M
LVR-0014
$800.00
plenti-EGFR (L858R)
LVR-0016
$800.00
plenti-EGFR (T790M)
LVR-0017
$800.00
plenti-EGFR (M766_A767insAI)
LVR-0018
$800.00
plenti-EGFR (H773_V774insH)
LVR-0019
$800.00
plenti-EGFR (Y764_V765insHH)
LVR-0020
$800.00
plenti-EGFR (Del19 (Del746-750) + T790M
LVR-0024
$800.00
plenti-EGFR (H773_V774insNPH)
LVR-0030
$800.00
plenti-HER2 (WT)
LVR-0031
$800.00
plenti-HER2 (S310F)
LVR-0032
$800.00
plenti-HER2 (A775_G776insYVMA)
LVR-0033
$800.00
plenti-HER2 (P780_Y781insGSP)
LVR-0034
$800.00
plenti-HER2 (P95)
LVR-0035
$800.00
plenti-EGFR (viii)
LVR-0036
$800.00
plenti-EGFR (A767_dupASV, C797S)
LVR-0037
$800.00
plenti-EGFR (D770_N771insSVD, C797S)
LVR-0038
$800.00
plenti-EGFR (H773_V774insH, C797S)
LVR-0039
$800.00
plenti-EGFR (L718Q, T790M, L858R)
LVR-0040
$800.00
plenti-EGFR (T790M, L792H, L858R)
LVR-0042
$800.00
plenti-EGFR (L792H, L858R)
LVR-0043
$800.00
plenti-HER2 (A775_G776insYVMA, C805S)
LVR-0044
$800.00
plenti MET WT
LVR-0050
$800.00
plenti MET del14
LVR-0051
$800.00
plenti MET D1228H
LVR-0052
$800.00
plenti MET D1228N
LVR-0053
$800.00
plenti MET Y1230H
LVR-0054
$800.00
plenti MET Y1230C
LVR-0055
$800.00
plenti MET Y1230S
LVR-0056
$800.00
plenti MET G1163R
LVR-0057
$800.00
plenti VEGFR WT
LVR-0058
$800.00
plenti VEGFR V916M
LVR-0059
$800.00
plenti VEGFR T925I
LVR-0060
$800.00
plenti EML4-ALK Fusion
LVR-0061
$800.00
plenti ALK G1202R
LVR-0062
$800.00
plenti ALK L1196M
LVR-0063
$800.00
plenti ALK I1171T
LVR-0064
$800.00
plenti ALK F1174L
LVR-0065
$800.00
plenti KIF5B-RET Fusion
LVR-0066
$800.00
plenti CCDC6-RET Fusion
LVR-0067
$800.00
plenti RET V804M
LVR-0068
$800.00
plenti RET V804L
LVR-0069
$800.00
plenti RET G810R
LVR-0070
$800.00
plenti RET G810S
LVR-0071
$800.00
plenti CD74-ROS1 Fusion
LVR-0072
$800.00
plenti EZR-ROS1 Fusion
LVR-0073
$800.00
plenti SDC4-ROS1 Fusion
LVR-0074
$800.00
plenti ROS1 G2032R
LVR-0075
$800.00
plenti ROS1 D2033N
LVR-0076
$800.00
plenti ROS1 S1986Y
LVR-0077
$800.00
plenti FLT3 D835Y
LVR-0113
$800.00
plenti FLT3 D835V
LVR-0114
$800.00
plenti FLT3 D835E
LVR-0115
$800.00
plenti FLT3 D835N
LVR-0116
$800.00
plenti FLT3 D835F
LVR-0117
$800.00
plenti FLT3 D835H
LVR-0118
$800.00
plenti FLT3 WT
LVR-0119
$800.00
plenti-JAK2 WT
LVR-0200
$800.00
plenti JAK2 V617F
LVR-0201
$800.00
plenti JAK2 T875N
LVR-0202
$800.00
plenti JAK2 R683G
LVR-0203
$800.00
plenti JAK2 Y931C + V617F
LVR-0204
$800.00
plenti JAK2 K539L
LVR-0205
$800.00
plenti JAK2 N542_E543del
LVR-0206
$800.00

Explore Related Cell Line Panels

 

We also offer a specialized panel of stable RTK-expressing Ba/F3 cell lines. Browse our existing inventory of pre-validated, high-demand oncogenic models:

Need a specific mutation not listed here? We specialize in Custom Stable Cell Line Generation Services tailored to your precise target and reporter requirements.

bottom of page