Lentiviral RTK Expression Vectors
Comprehensive Systems for Signal Transduction, Oncology, and Drug Screening
Signosis offers a diverse collection of fully sequenced lentiviral Receptor Tyrosine Kinase (RTK) expression vectors designed for high-efficiency transduction across a wide array of cell lines.
Because traditional transfection methods often fall short in primary cells, suspension lines, or hard-to-transfect targets, our lentiviral delivery platforms ensure robust, long-term, and stable expression of key RTK families. Whether you are investigating normal signal transduction pathways or modeling cancer-driving mutations and acquired drug resistance, our vectors provide a reliable foundation for your assays.
Advantages of Signosis Lentiviral RTK Expression Vectors
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Efficiently deliver and express genes of interest in both dividing and non-dividing cells, including primary cells and suspension lines.
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Contains essential elements (HIV-1 LTRs, packaging signals, WPRE, and cPPT) for enhanced viral titer yields and transcript stability.
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Strong Promoters: Powered by optimized viral MSCV promoter for high-level expression of your target kinase.
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Selection & Reporting: Vectors feature fluorescent copGFP reporter markers driven by independent EF-1 promoter, with optional Antibiotic selection of your choice for easy tracking and clean selection including:
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G418
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Puromycin
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Optional terminal tags (such as FLAG or HA) may be included to simplify protein tracking and Western blot validation.
Major RTK Families Available
Our growing catalog covers critical receptor tyrosine kinase families involved in growth, differentiation, angiogenesis, and oncogenesis:
EGFR
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Classical-Like Mutations (e.g., L858R, Del19)
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T790M-like Mutations (e.g., T790M, L792H, C797S)
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Exon 20 Loop Insertions (e.g., H773_V774insNPH)
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PACC Mutations (e.g., L718Q)
FLT3
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Wild-Type Kinase Domain Variants:
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D835H/F/N/E/V/Y
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VEGFR (KDR/FLK-1)
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Wild-Type and Kinase Domain Variants:
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VEGFR2 (KDR) WT
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V916M
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T925I
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ALK
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Fusions: EML4-ALK (Variants 1, 2, and 3)
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Resistance Variants:
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G1202R
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L1196M
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I1171T
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F1174L
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ROS1
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Fusions: CD74-ROS1, EZR-ROS1, SDC4-ROS1
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Resistance Variants:
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G2032R
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D2033N
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S1986Y
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HER2
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ECD Mutations: S310F
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Truncated Isoform: p95
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Kinase Domain Variants:
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A775_G776insYVMA
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P780_Y781insGSP
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and more
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JAK2
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Wild-Type Kinase Domain Variants:
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V617F
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V617F + EPOR
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T875N
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R683G
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and more
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MET
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Exon 14 Skipping: MET ex14del
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Kinase Domain Resistance
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Y1230H/C/S
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D1228N/H
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G1163R
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RET
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Fusions: KIF5B-RET, CCDC6-RET
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Resistance Variants:
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V804M
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V804L
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G810R
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G810S
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Products
Explore Related Cell Line Panels
We also offer a specialized panel of stable RTK-expressing Ba/F3 cell lines. Browse our existing inventory of pre-validated, high-demand oncogenic models:
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EGFR Mutant & Resistance Panels (Featuring T790M, C797S, and complex compound mutations)
Need a specific mutation not listed here? We specialize in Custom Stable Cell Line Generation Services tailored to your precise target and reporter requirements.