Two key transcription factors, Oct4 and Sox2, have been identified that are crucial for maintenance of the pluripotent state of ESCs. Octamer 3/4 (Oct 3/4), a member of the POU family, is considered to be an important stem cell marker and essential transcription factor during human embryogenesis. Sox2 is a member of the Sox (SRY-Related HMG box) gene family that encodes transcription factors with a single HMG DNA-binding domain. Sox2 controls neural progenitor cells by prohibiting their ability to differentiate. In recent years, there have also been reports about the presence of Oct 3/4 and Sox2 in differentiated benign and malignant human cells. Oct4 and Sox2 showed cooperative binding to the Sox-Oct motifs on some target promoter regions. In addition, the transcription factor Nanog, an established regulator of pluripotency, is transcriptionally regulated directly by Oct4 and Sox2.
OCT4 ELISA Kit (Colorimetric)
SKU: TE-0031
$828.00Price
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