Transcriptional co-regulators interact specifically and non-covalently with one or multiple DNA-binding transcription factors (TFs) to either activate or repress the transcription of specific genes. Dysregulated expression of coregulator, such as SRC-1/NcoA-1, p300, CBP and HADC, has a significant effect on the regulation of a TF in the recruitment of other transcription factors and chromatin remodeling.  For example, the upregulation of SRC-1 has known roles in mediating steroid receptor transcription in androgen receptor activity as well as prostate cancer progression.
Signosis has developed TF-Coregulator Interaction Plate Array Assay II allowing for high throughput studying of co-regulator interaction networks with 48 different TFs.