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Promoter-Binding Profiling Plate Arrays
Signosis' TF Promoter Binding Assay allows you to profile up to 96 transcription factors binding to a promoter in a single experiment. This high-throughput solution saves time, reduces costs, and offers a comprehensive view of gene regulation, helping you explore complex transcriptional networks in cancer, metabolic disorders, and neurodegeneration.
Principle
Signosis' Promoter-Binding TF profiling plate arrays use a competition-based method to identify transcription factors (TFs) bound to a specific promoter. In this assay, biotin-labeled oligos and your PCR promoter fragment are mixed with your sample. If an unlabeled promoter DNA containing a TF binding sequence is present, it competes with the biotin-labeled oligos, reducing complex formation and detection. By comparing results with and without the competitor DNA, you can identify the TFs interacting with the promoter.
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Products
Product Name | SKU | Price | Number of Samples |
|---|---|---|---|
Promoter-Binding TF Profiling Array I with the Nuclear Extraction Kit | $1154.00 | 4 | |
Promoter-Binding TF Profiling Array I | $976.00 | 4 | |
Promoter-Binding TF Profiling Array II with the Nuclear Extraction Kit | $1516.00 | 4 | |
Promoter-Binding TF Profiling Array II | $1337.00 | 4 |
Specifications
Promoter-Binding TF Array I
HIGH THROUGHPUT
Can profile up to 96 transcription factors (TFs) binding to a promoter of interest in a single experiment.
SAMPLE TYPE
requires nuclear extract as the starting material, which can either be purchased with the kit or separately. The nuclear extract, catalog number SK-0001, is suitable for both mammalian tissue and cultured cells.
# OF SAMPLES
Able to run up to 4 samples.
CUSTOMIZATION
We offer the flexibility to customize the plate or synthesize a specific transcription factor if the one you need is not available in our standard kit. Let us know your requirements, and we can tailor the assay to suit your research needs.
Benefits
High-Throughput Efficiency
Profile 96 TFs in one experiment, saving time and resources.
Cost-Effective
Reduce costs by eliminating multiple single-TF experiments.
Comprehensive Insights
Gain a complete view of TF-promoter interactions for deeper understanding.
Broad Applications
Suitable for cancer, metabolic diseases, neurodegeneration, and more.
Easy to Use
Simplified workflow delivers results in hours.
Competition-Based Precision
Accurately identify promoter-bound TFs using unlabeled DNA fragments competing with biotin-labeled TF-binding oligos.
