Epidermal growth factor (EGF) is a strong mitogen for many cells, such as fibroblasts. EGF also stimulates the proliferation of embryonic cells. The proliferation of some cell lines has been shown to be inhibited by EGF. EGF acts as a differentiation factor for some cell types. To a limited extent EGF also augments angiogenesis because it is mitogenic for endothelial cells. The mitogenic activity of EGF for endothelial cells can be potentiated by thrombin. EGF is a strong chemoattractant for fibroblasts and epithelial cells. EGF alone and also in combination with other cytokines is an important factor mediating wound healing processes.
 
Detection Range:
    16 - 1000 pg/mL
Sensitivity:
    10 pg/mL