The Iron Responsive Element, IRE RNA EMSA Kit is designed to detect RNA-protein interactions involving IRE-containing RNA models. IREs are classic translational control elements recognized by IRP1 and IRP2, which regulate iron metabolism by controlling the translation or stability of iron-related mRNAs.
This kit is useful for researchers studying iron homeostasis, metabolism, oxidative stress, anemia, cancer metabolism, and translational regulation. The RNA EMSA format allows detection of IRP binding activity and comparison of RNA-protein interactions under different cellular or treatment conditions.