Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a crucial role in regulating the body's response to oxidative stress and maintaining cellular homeostasis. The NRF2/ARE luciferase reporter vector is used to measure the transcriptional activity of NRF2 by using a luciferase reporter gene under the control of Antioxidant Response Elements, which are specific DNA sequences that are recognized by NRF2.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.