The thyroid hormone receptor (TR) is a nuclear receptor that regulates gene expression for various physiological processes, including metabolism, growth, development, and differentiation. The TR luciferase reporter vector is designed to study the transcriptional activity of this receptor. The vector contains a TR DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report TR activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.