SRY-box transcription factor 5 (SOX5) is a transcription factor that plays a crucial role in regulating a wide range of developmental processes, including cell fate determination, differentiation, proliferation, and morphogenesis. The SOX5 luciferase reporter vector is designed to study the transcriptional activity of SOX5. The vector contains a SOX5 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report SOX5 activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.