Receptor tyrosine kinases (RTKs) play important roles in converting extracellular to intracellular signals.They are activated by the binding of specific growth factors, cytokines, or hormones, which results in autophosphorylation. Tyrosine autophosphorylation generates recruitment sites for downstream signaling proteins containing Src homology-2 (SH2). Binding of different SH2 domain-containing signaling proteins represents the activation of different signaling pathways. Therefore, the activation of signaling pathways can be assessed through examination of SH2 domain binding. Signosis provided SH2 Domain-Based RTK Profiling Plate Array, which allows assessing the activation of RTK signaling pathways through the examination of 46 SH2 domain binding simultaneously.