The Wnt signaling pathway is important to both embryonic development and tumorigenesis. �-Catenin, the central component of the pathway, functions as a co-factor of the TCF/LEF family of transcription factors.  Together, they activate transcription of Wnt target genes by binding to the promoters of downstream target genes involved in cell proliferation, survival, and migration. Signosis� Wnt/�-Catenin signaling pathway cDNA plate array can simultaneously measure the expression of 20+ genes that participate in the pathway and can compare the differences in the expression of these genes in different samples.
Signosis has developed a plate-based array for profiling 20+ Wnt-regulated genes. By using this assay, researchers are able to compare gene expression in up to three samples on a single microtiter plate.