Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) is a family of nuclear receptors that plays an essential role in the regulation of developmental processes, cell differentiation, metabolism, and neurogenesis. The COUP-TF luciferase reporter vector is designed to study the transcriptional activity of COUP-TF. The vector contains a COUP-TF DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report COUP-TF activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.