Polybrene (hexadimethrine bromide) is a cationic polymer widely used to enhance lentiviral and retroviral transduction efficiency. By neutralizing charge repulsion between negatively charged viral particles and the cell surface, Polybrene promotes closer interaction and increases viral entry into target cells.
Signosis Polybrene Infection / Transduction Reagent is optimized to improve gene delivery efficiency across a broad range of mammalian cell types while maintaining low cytotoxicity. It is ideal for use in stable cell line generation, gene overexpression studies, and functional screening applications. When incorporated into lentiviral workflows, Polybrene helps maximize transduction rates and ensures consistent experimental outcomes.