The pLP2 vector is a lentiviral packaging plasmid designed to provide essential regulatory proteins required for efficient lentiviral particle production. Specifically, pLP2 supplies the Rev protein, which facilitates nuclear export of viral RNA transcripts during packaging, thereby enhancing viral assembly and overall titer.
Used in combination with pLP1(SKU: ELM-0013), pLP/VSV-G envelope plasmid (SKU: ELM-0015), and a lentiviral transfer vector with PEI transfection reagent (SKU: CC-0011), pLP2 contributes to the generation of replication-deficient lentiviral particles in HEK293T producer cells. Its optimized design ensures reliable viral production while maintaining biosafety, making it an important component of a robust and scalable lentiviral expression system.