The pLP/VSVG vector is an envelope plasmid used in lentiviral packaging to provide the vesicular stomatitis virus glycoprotein (VSV-G), which pseudotypes the lentiviral particles. Expression of VSV-G enables efficient viral assembly and broad tropism, allowing the produced lentivirus to infect a wide range of dividing and non-dividing mammalian cells.
When co-transfected with packaging plasmids, pLP1 (SKU: ELM-0013) and pLP2 (SKU: ELM-0014) and a lentiviral transfer vector in HEK293T producer cells (SKU: PC-023) using PEI Transfection reagent (SKU: CC-0011), pLP/VSVG facilitates the generation of high-titer, replication-deficient lentiviral particles. Its robust envelope expression enhances viral stability and transduction efficiency, making it an essential component of a reliable and scalable lentiviral production system.