The pLP1 vector is a lentiviral packaging plasmid designed to supply essential viral structural and enzymatic proteins required for efficient lentiviral particle production. During transient transfection of producer cells, pLP1 provides the gag and pol genes necessary for viral assembly, reverse transcription, and integration, while lacking packaging signals to ensure replication-deficient virus generation.
Used in combination with a transfer vector, pLP2 (SKU: ELM-0014) and pLP/VSVG envelope plasmid (SKU: ELM-0015) using PEI Transfection Reagent (SKU: CC-0011), pLP1 enables high-titer, safe, and reliable lentiviral production. Its optimized configuration supports consistent viral assembly and robust performance in HEK293T-based packaging systems, making it a critical component of an efficient and scalable lentiviral expression workflow.