The retinoid X receptor (RXR) is a nuclear receptor that plays a key role in regulating gene expression in response to retinoids and other lipid-soluble signaling molecules. The RXR luciferase reporter vector is designed to study the transcriptional activity of this receptor. The vector contains an RXR DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report RXR activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.