TEA domain transcription factor 1 (TEAD1) is a transcription factor that plays a significant role in the Hippo signaling pathway and regulates gene expression involved in cell growth, differentiation, and tissue homeostasis. The TEAD1 luciferase reporter vector is designed to study the transcriptional activity of TEAD1. The vector contains a TEAD1 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report TEAD1 activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.