X-box binding protein 1 (XBP1) is a transcription factor that plays a central role in the unfolded protein response, a cellular stress response to the accumulation of misfolded proteins in the endoplasmic reticulum. The XBP1 luciferase reporter vector is designed to study the transcriptional activity of XBP1. The vector contains a XBP1 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report XBP1 activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.