The Wnt signaling pathway is important to both embryonic development and tumorigenesis. β-Catenin, the central component of the pathway, functions as a cofactor for a number of transcription factors. These transcription factors then activate transcription of Wnt target genes involved in cell proliferation, survival, and migration. Characterization of the activation of TF involved in the Wnt/ β-Catenin pathway can lead to greater understanding of various disease states and the development of treatments. Signosis has developed the Wnt/β-Catenin TF Activation Profiling Plate Array, which can be used to simultaneously monitor 16 Wnt/β-Catenin related TFs, including AP-1, CEBP, c-Myc, GBX2, GLI-1, Mitf, NFAT, NR5A2, Oct3/4, OLIG1, Pitx2, PRop1, Sox2, TCF/LEF, and VAX2.