Insulin resistance is a complex condition that involves dysregulation of multiple transcription factors, which can lead to a variety of metabolic abnormalities. The Insulin Resistant Transcription Factor Activation Plate Array developed by Signosis provides a valuable tool for researchers to simultaneously monitor the activities of 16 Insulin Resistant-related TFs, including AP2, CREB, EGR-1, FOXO1, HNF-1, HSF-1, LXR, MAFA, NEUROD, NKX2.2, NKX6.1, PAX4, PAX6, PDX-1, PPAR, and SREBP1. This can help researchers better understand the mechanisms underlying insulin resistance and potentially identify new therapeutic targets for the treatment of type 2 diabetes and other metabolic disorders.