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Anti-nuclear antibodies (ANA) are a group of antibodies directed against various nuclear and some cytoplasmic antigens. Although these antibodies were first associated with systemic lupus erythematosus (SLE), the list of implicated diseases has expanded and many rheumatic diseases are characterized by the presence of one or more of these ANAs. For instance, anti-SSA/Ro and anti-SSB/La antibodies are associated with SLE and Sjögren’s Syndrome (SS), anti-dsDNA and anti-Sm antibodies with SLE, anti-histone antibodies with SLE and Drug Induced Lupus, anti-RNP antibodies with mixed connective tissue disease (MCTD) and SLE, anti-Scl-70 antibodies with scleroderma (progressive systemic sclerosis (PSSJ), anti-Jo1 with polymyositis and dermatomyositis and anti-centromere antibodies with CREST syndrome. ANA are usually detected by indirect immunofluorescence (IFA) on HEp-2. Because of certain limitations of IFA, ANA ELISA test is more robust offering several advantages including ease of operation and not requiring skills needed to perform and read IFA reactions. ANA ELISA test is able to efficiently screen large numbers of patient samples and reduces human error. As ANA ELISA test collectively detects, in one well, total ANAs against double stranded DNA (dsDNA), Histones, SS-A/Ro, SS-B/La, Sm, Sm/RNP, Scl-70, Jo-1, and centromeric antigens, more specific antibody tests are recommended to perform in patients with positive ANA.

Human ANA ELISA Kit

SKU: EA-5013
$570.00Price

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