Anti-dsDNA antibodies that appear to be critical in the pathogenesis of tissue injury are characteristic of systemic lupus erythematosus (SLE). There is a good correlation between anti-dsDNA antibody levels and disease activity. The overall detection rate of these antibodies is approximately 50-55% in SLE patients and about 89% in SLE patients with active renal disease. When they are present in high concentration, anti-dsDNA antibodies are virtually specific for SLE (>90%). Antibodies to dsDNA may disappear with immunosuppressive treatment and during remission. They rarely occur in other autoimmune disorders. Signosis has developed anti-dsDNA ELISA, a sandwich quantitative assay, to screen the presence of serum ds-DNA antibodies IgG.
Detection Range:
4 - 125 ng/mLSensitivity:
0.5 ng/mL
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SKU: EA-5002
$570.00Price
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