MEF cells are primary fibroblasts derived from mouse embryos and are widely used in basic and translational research. They exhibit typical fibroblast morphology, are highly proliferative, and serve as a versatile model for cell signaling, gene function studies, genetic manipulation, reprogramming, and drug screening. MEFs are commonly employed in studies of development, senescence, apoptosis, and cellular stress responses, making them a foundational tool for both mechanistic research and biotechnology applications.
The cells should be handled at laboratory containment level 1.