The Signosis FUS RNA EMSA Kit offers a complete, non-radioactive system to study FUS–RNA interactions using biotin-labeled RNA probes and native gel electrophoresis.
FUS (Fused in Sarcoma) is a multifunctional RNA-binding protein involved in RNA splicing, transport, translation, and stress granule formation. FUS binds specific RNA motifs, often rich in GGUG or G-quartet sequences, and its interactions are implicated in neurodegenerative diseases like ALS and frontotemporal dementia. This EMSA kit enables visualization of FUS–RNA complexes, which migrate slower than unbound RNA, making it ideal for confirming RNA targets, assessing binding specificity, or comparing wild-type versus mutant RNAs or FUS variants.