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Colorful Disks

EGFR Vectors

pMSCV-EGF-GFP Vectors 

pCMV-EGFR Vectors 

pLenti-MSCV-EGFR-GFP Vectors

pCMV-EGFR Vectors

Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor that plays a critical role in regulating cell division and death.  Mutations in EGFR gene that lead to overexpression of the protein have been associated with a number of different cancers. The EGFR gene is present on chromosome 7p11.2 and has 28 coding exons in which exons 5–7 and 13–16 code for the ligand-binding domain and exons 18–24 code for the TK domain.  

 

Downstream effects of EGFR activation include modulation of three major pathways of RAS-RAF-MAPK, PI3K/AKT, and JAK/STAT pathways which can lead to cell survival, proliferation, and migration of cancer cells.

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We offer a collection of unique cloning and expression cDNA vectors contain WT and mutated EGFR gene. These mutations are clinically approved and are under further investigation by many researchers. Our high-quality vectors are fully sequenced and are ready to use. We also offer custom cloning services for your specific construct needs.

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pMSCV-EGF-GFP Vectors Research Application

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  • Overexpressing EGF in cells to study the effects of EGF on cell proliferation, differentiation, and survival.

  • Generating stable cell lines expressing EGF for long-term studies of EGF signaling pathways and downstream effects.

  • Investigating the mechanisms of resistance to EGF inhibitors or combination therapies in cells that overexpress EGF.

  • Developing animal models of EGF-driven cancers by transfecting cells with pMSCV-EGF-GFP vectors and injecting them into animals.

  • Evaluating the efficacy of various inhibitors or combination therapies targeting EGF in vitro and in vivo.

pCMV-EGFR Vectors

EGFR mutations fig created 12-11-2017.jpg

Benefits

pLenti-MSCV-EGFR-GFP Vectors

Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor that plays a critical role in regulating cell division and death.  Mutations in EGFR gene that lead to overexpression of the protein have been associated with a number of different cancers. The EGFR gene is present on chromosome 7p11.2 and has 28 coding exons in which exons 5–7 and 13–16 code for the ligand-binding domain and exons 18–24 code for the TK domain.  Downstream effects of EGFR activation include modulation of three major pathways of RAS-RAF-MAPK, PI3K/AKT, and JAK/STAT pathways which can lead to cell survival, proliferation, and migration of cancer cells.

​

We offer a collection of unique cloning and expression cDNA vectors contain WT and mutated EGFR gene. These mutations are clinically approved and are under further investigation by many researchers. Our high-quality vectors are fully sequenced and are ready to use. We also offer custom cloning services for your specific construct needs.

pCMV-EGFR Vectors Research Application

​

  • Overexpressing EGFR in cells to study the effects of EGFR on cell proliferation, differentiation, and survival.

  • Generating stable cell lines expressing EGFR for long-term studies of EGFR signaling pathways and downstream effects.

  • Investigating the mechanisms of resistance to EGFR inhibitors or combination therapies in cells that overexpress EGFR.

  • Developing animal models of EGFR-driven cancers by transfecting cells with pCMV-EGFR vectors and injecting them into animals.

  • Evaluating the efficacy of various inhibitors or combination therapies targeting EGFR in vitro and in vivo.

pLenti-MSCV-EGFR-GFP Vectors

pLenti-MSCV-EGFR-GFP.png

Benefits

pLenti-MSCV-EGFR-GFP Vectors

Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor that plays a critical role in regulating cell division and death.  Mutations in EGFR gene that lead to overexpression of the protein have been associated with a number of different cancers. The EGFR gene is present on chromosome 7p11.2 and has 28 coding exons in which exons 5–7 and 13–16 code for the ligand-binding domain and exons 18–24 code for the TK domain.  Downstream effects of EGFR activation include modulation of three major pathways of RAS-RAF-MAPK, PI3K/AKT, and JAK/STAT pathways which can lead to cell survival, proliferation, and migration of cancer cells.

​

We offer a collection of unique cloning and expression cDNA vectors contain WT and mutated EGFR gene. These mutations are clinically approved and are under further investigation by many researchers. Our high-quality vectors are fully sequenced and are ready to use. We also offer custom cloning services for your specific construct needs.

pLenti-MSCV-EGFR-GFP Vectors Research Application

​

  • Generating stable cell lines expressing EGFR for long-term studies of EGFR signaling pathways and downstream effects.

  • Investigating the effects of EGFR mutations on downstream signaling pathways and cellular processes, such as cell proliferation, differentiation, and survival.

  • Identifying novel therapeutic strategies for targeting EGFR in cancer by testing the efficacy of various inhibitors or combination therapies.

  • Screening for small molecule compounds or antibodies that selectively target EGFR mutants over wild-type EGFR.

  • Developing animal models of EGFR-driven cancers by transfecting cells with pLenti-MSCV-EGFR-GFP vectors and injecting them into animals.

  • Evaluating the potential of EGFR and its mutants as diagnostic and prognostic biomarkers for specific types of cancer.

Benefits

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