Forkhead-related activator (FREAC) is a transcription factor that plays a critical role in regulating cell growth, differentiation, metabolism, and immune responses. The FREAC luciferase reporter vector is designed to study the transcriptional activity of FREAC. The vector contains a FREAC DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report FREAC activity while maintaining a low basal level of transcription. It also contains the Renilla Luciferase under the CMV promoter for data normalization.