HOX4C is a member of the HOX gene family and plays a crucial role in development, particularly in embryonic patterning and cell fate determination. The HOX4C luciferase reporter vector is designed to study the transcriptional activity of HOX4C. The vector contains a HOX4C DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report HOX4C activity while maintaining a low basal level of transcription. It also contains the Renilla Luciferase under the CMV promoter for data normalization.