Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) is a transcription factor that plays a central role in regulating the immune response, inflammation, and cell survival. The NFκB luciferase reporter vector is designed to study the transcriptional activity of NFκB. The vector contains an NFκB DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report NFκB activity while maintaining a low basal level of transcription. It also contains the Renilla Luciferase under the CMV promoter for data normalization.