NFE2 is a transcription factor that plays a key role in the regulation of erythropoiesis and other hematopoietic processes. The NFE2 luciferase reporter vector is designed to study the transcriptional activity of NFE2. The vector contains an NFE2 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report NFE2 activity while maintaining a low basal level of transcription. It also contains the Renilla Luciferase under the CMV promoter for data normalization.