Metabolism/FXR/RAR/AARE
Principle
Metabolism is controlled by transcription factors that respond to cellular signals and environmental changes. The Farnesoid X Receptor (FXR) and Retinoic Acid Receptor (RAR) are crucial in this regulation. FXR, a nuclear hormone receptor, binds to DNA hormone response elements (HREs) in response to lipophilic ligands, influencing lipid and glucose metabolism, and impacting conditions like diabetes and obesity. RAR, activated by retinoic acid, also affects metabolic processes and cellular differentiation. In addition, cells respond to metabolic stress through pathways like the Amino Acid Response (AAR) pathway via binding to AAR binding element to regulate amino acid metabolism.
Signosis has provide a number of Reporter Stable Cell Lines for different metabolic pathways, including PXR, RAR, and AARE (Amino acid response element).
Benefits
High Sensitivity & Responsiveness
Each cell line is validated to induce a strong reporter signal in response to stimuli.
Consistent
TF reporter construct is stably integrated into the genome to avoid experimental/cell-to-cell variations.
Time-Saving
Cell line can be used for experiments right away to study different signaling pathways.
Routine Mycoplasma Testing
All cell lines tested negative for mycoplasma.
