Metabolism/FXR

Farnesoid X receptor (FXR, NR1H4) is a member of the nuclear hormone receptor superfamily. These nuclear hormone receptors are ligand-activated transcription factors that elicit their actions by binding to hormone response elements (HREs) in the promoters of target genes and regulating transcription in response to lipophilic ligands.

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Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer with RXR and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes, involved in lipid and glucose homeostasis which play a crucial role in pathophysiology of many major diseases such as diabetes, obesity, atherosclerosis and heart failure. In addition, FXR activation has been shown to be critical in the regulation of inflammatory responses.

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Signosis now offers FXR-Luciferase reporter stable cell line to the research community. This high-quality stable cell lines will facilitate further molecular studies of FXR pathway and its functions.

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