Wilms Tumor 1 suppressor protein 1 (WT1) is a transcription factor that is associated with kidney cancer and is involved in various processes such as kidney development, gonadogenesis, and hematopoiesis. The WT1 luciferase reporter vector is designed to study the transcriptional activity of WT1. The vector contains a WT1 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report WT1 activity while maintaining a low basal level of transcription.
 
The inclusion of a neomycin resistance gene in the vector allows it to be used for stable cell line selection. In addition, the vector also has a GFP-tag which can be used to monitor transfection efficiency. A map of the vector can be found in the product's image gallery.