Biomarkers are defined as biological indicators of a physiological or disease process that has clinical utility or drug discovery. Signosis is a molecular tool company that is focusing on development of innovative and unique products for biomarker discovery and analysis in the areas of life science research, clinical application and drug discovery. Our mission is to become a worldwide provider with a broad spectrum of more sensitive, cost-effective, rapid assay products to target biomarkers such as disease-related proteins, mRNAs, microRNAs, epigenetic variations, splice variants and SNPs, with emphasis in a number of diseases including cancers, diabetes/obesity, and cardiovascular diseases.
Available!MicroRNA Research
MicroRNAs (miRNAs) are important to the regulation of gene expression. Profiling of miRNA expression is proving to be an efficient approach to discovering the association of miRNAs with a biological relevance and to identify the signature of miRNA expression in human diseases. Signosis’ miRNA array technology allows highly sensitive and discriminative profiling of miRNAs without pre-isolation of miRNA. In additon, Signosis' miRNA plate assays, northern blot assay kits, and luciferase reporter vectors provide assays to target individual miRNAs for expression, array validation, in vivo analysis, etc.
ELISA Profiling Strips
Cytokines and growth factors are essential molecules that play crucial roles in many biological functions, including viral infrection, inflammation, immunity, hematopoiesis, angiogenesis and proliferation. Measurement of multiple cytokines and growth factors at a same time provides an effective appraoch to uncover the mechanism underlying biological functions. Signosis developed a number of ELISA profiling strip kits for monitoring 8 cytokines or growth factors, which can be used for analyzing angiogenesis, inflammation, and obesity in human and mouse samples.
What's new?
(1) Single cell RT-PCR for analyzing gene expression in a few cells.
(2) Buffer for preparing cell lysates, whcih can be directly used for RT-PCR.
(3) High sensitive detection of mRNA directly in cell lysates without RNA preparation, reverse transcription, and PCR for the measurement of gene expression.
(4) Profiling expression of a group of genes with Signosis' cDNA plate arrays, including NFkB-, p53-, HIF-, and Stat3-regulated cDNA plate arrays to measure expression of 20+ target genes.