Estrogen Receptor
Principle
Estrogen receptor (ER) belongs to nuclear receptor family and plays a widespread role in human physiology and in the development or progression of numerous diseases. In response to estrogen stimulation, estrogen bound receptor in the nucleus dimerizes and binds to specific response elements known as estrogen response elements (EREs) located in the promoters of target genes and regulates their gene expression.
Signosis has established luciferase reporter stable cell lines, in which the ERE and reporter luciferase gene are consistently expressed in the cell line to facilitate the screening and study. These stable cell line can provide a sensitive, responsive, and rapid in vitro system to detect and measure substances with potential (anti-)estrogenic activity.
Benefits
High Sensitivity & Responsiveness
Each cell line is validated to induce a strong reporter signal in response to stimuli.
Consistent
TF reporter construct is stably integrated into the genome to avoid experimental/cell-to-cell variations.
Time-Saving
Cell line can be used for experiments right away to study different signaling pathways.
Routine Mycoplasma Testing
All cell lines tested negative for mycoplasma.
