Biological function
PTBP1 is a key splicing regulator that often represses inclusion of alternative exons. It also participates in IRES-mediated translation and mRNA localization.
 
Binding property
PTBP1 prefers CU-rich polypyrimidine tracts, often repeated UCUU/CUCU motifs in introns or UTRs. Binding typically alters splice site choice or translation.
 
Assay notes
Uses a CU-rich RNA probe optimized for strong PTBP1 binding. Useful for studying splicing regulation and PTBP1-targeted mechanisms.