Biological function
Pumilio proteins are translational repressors that control mRNA stability and translation in development, neurobiology, and germline maintenance.
 
Binding property
Pumilio recognizes a short consensus known as the Pumilio response element (PRE), typically UGUANAUA in 3′UTRs. Binding recruits effector complexes that repress translation or promote decay.
 
Assay notes
Probe contains a canonical UGUANAUA motif. This kit is useful for analyzing Pumilio pathway activity across diverse cell types.