Stable Cell Lines
Ready-to-Use, Reliable TF Reporter Stable Cell Lines
Eliminate the hassle of in-house development with Signosis' pre-validated stable cell lines, optimized for gene function analysis, target discovery, and assay development.
Our cell lines are mycoplasma-free, batch-to-batch reproducible, and ready to integrate seamlessly into your research, saving you valuable time and resources.
Key Benefits:
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Validated & Ready-to-Use: No more time-consuming in-house development. Our cell lines come pre-validated for reliable and consistent performance in a range of applications, from gene expression studies to drug screening.
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High Sensitivity, Low Background: Designed for high sensitivity with minimal background, ensuring accurate results in your assays every time.
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Cost-Effective: Save on both development time and resources. Our optimized production processes allow us to offer high-quality cell lines at a fraction of the cost of traditional methods.
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Batch-to-Batch Consistency: Enjoy reliable, reproducible results across multiple experiments with our rigorously tested stable cell lines, reducing variability in your research.
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Global Accessibility: Available worldwide with fast and reliable shipping, Signosis stable cell lines are accessible to researchers globally, regardless of location.
Scientific Foundation & Transformative Applications
Background
Signosis' Stable Cell Lines function as critical resources in scientific studies. From gene function analysis, target discovery and validation, assay development, and compound screening, a variety of research require cell-based assays. At Signosis, we offer high-quality, ready-to-use stable cell lines to help researchers save time and labor in generating and validating stable cell lines so that scientists world-wide can spend more effort on solving the big questions.
Molecular Application
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Our key research kits
Cell Lines for monitoring Transcription Factor binding and activation
Signosis' cell lines for monitoring TF binding and activation offers a powerful and reliable solution. With a choice of two versatile luciferase reporter systems, we offer a wide selection of validated luciferase reporter cell lines that measure transcription factor activity as a read-out for various signaling pathways.
Isoform-Specific NHR Reporter Stable Cell Lines
Signosis's Isoform-Specific NHR Reporter Stable Cell Lines leverage the GAL4 two-hybrid system by fusing the ligand-binding domain (LBD) of a specific NHR isoforms to the GAL4 DNA-binding domain. This design enables isoform-specific detection of receptor activation based on functional response, allowing for precise, discriminative analysis of nuclear receptor activity
G protein-coupled receptor (GPCR) Luciferase Reporter Cell Lines
Signosis’ GPCR luciferase reporter cell lines provide a sensitive and robust tool for monitoring GPCR activation through cAMP-mediated signaling pathways. Utilizing CRE-driven luciferase expression as a readout, these validated cell lines enable measurement of Gs-coupled receptor activity in response to ligand stimulation, ideal for drug screening and pathway analysis.
Receptor Tyrosine Kinase Mutation Cell Line Panels
Signosis offers BaF3 stable cell lines expressing specific mutant tyrosine kinases, including clinically relevant EGFR variants, validated for signaling studies and inhibitor screening. Our cell line panel includes other RTKs mutations such as HER2 and FLT3, as well as the non-receptor Tyrosine Kinase JAK2, expanding utility across multiple oncogenic pathways.
Luciferase Substrate
We offer highly sensitive, ready-to-use one-solution substrates for detecting Firefly, Renilla, and Gaussia luciferase. These substrates are extensively validated with our Luciferase Reporter Stable Cell Lines, reporter vectors, and other commercial systems using these luciferases. Designed for ease of use and reliable performance, they support a wide range of gene expression and cellular pathway studies.
Cell Viability & Proliferation Assays
ATP, XTT, and WST-8 assays are essential tools for measuring cell viability and proliferation in biomedical and pharmaceutical research. These convenient and reliable assays provide researchers with flexible options for evaluating cellular health, cytotoxicity, and the effects of drugs or treatments across a wide range of experimental conditions.
Products
Stable Cell Line Products
