Description(s):
The proto-oncogene human epidermal growth factor receptor 2 (HER2) gene also known as ERBB2 is a member of the ERBB/HER RTK family which is comprised of EGFR (EGFR/HER1/ERBB1), HER3/ERBB3, and HER4/ERBB4. This gene encodes for a transmembrane glycoprotein receptor with an intracellular domain with tyrosine kinase activity which is responsible for the activation of intracellular signal transduction pathways controlling epithelial cell growth, differentiation, and angiogenesis. Aberrations of the HER2 gene which usually leads to increased receptor signaling have been observed in many different types of cancer.
 
ERBB2 (HER2) A775_G776insYVMA results in the insertion of four amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 775 and 776.  ERBB2 (HER2) C805S lies within the protein kinase domain of the Erbb2 (Her2) protein. C805S is associated with resistance to Erbb2 (Her2)-targeted therapies.
 
The cell line can be used for studying ErbB/HER signaling pathway.
The cell line can be used for screening or evaluating related drugs/compounds.
The cell line is viral-vector free.
Transfected Her2 gene sequence and its expressed protein have been confirmed.
The cell line is mycoplasma-free.