The Wnt/β-Catenin signaling pathway is a key regulator of embryonic development, cell proliferation, survival, and tumorigenesis. β-Catenin partners with TCF/LEF transcription factors to activate genes critical for these processes.

Signosis offers a range of validated TCF/LEF luciferase reporter stable cell lines designed to monitor the transcriptional activity of the Wnt/β-Catenin pathway in live cells. These cell lines contain reporter vectors with 6 repeats of TCF/LEF binding sites driving luciferase expression, allowing sensitive and quantitative detection of β-catenin-mediated pathway activation.

Our reporter cell lines enable researchers to study Wnt pathway activation triggered by extracellular signals, gene overexpression, knockdown, or pharmacological treatments. They provide robust, reliable tools for applications in developmental biology, cancer research, stem cell biology, and drug discovery.

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