Stable Cell Lines

Ready-to-Use, Reliable, and Time-Saving
Eliminate the hassle of in-house development with pre-validated stable cell lines for gene function analysis, target discovery, and assay development.

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Scientific Foundation & Transformative Applications

Background

Signosis' Stable Cell Lines function as critical resources in scientific studies. From gene function analysis, target discovery and validation, assay development, and compound screening, a variety of research require cell-based assays. At Signosis, we offer high-quality, ready-to-use stable cell lines to help researchers save time and labor in generating and validating stable cell lines so that scientists world-wide can spend more effort on solving the big questions.

Molecular Application
Slideshow

Studying Signaling Pathways

Reporter stable cell lines be engineered to allow real-time monitoring of TF transactivation, which is ideal for drug screening, signaling studies, regulation analysis, and more.

Service Workflow

Our key research kits

Cell Lines for monitoring Transcription Factor binding and activation

Signosis' cell lines for monitoring TF binding and activation offers a powerful and reliable solution. With a choice of two versatile luciferase reporter systems, we offer a wide selection of validated luciferase reporter cell lines that measure transcription factor activity as a read-out for various signaling pathways.

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Isoform-Specific NHR Reporter Stable Cell Lines

Signosis's Isoform-Specific NHR Reporter Stable Cell Lines leverage the GAL4 two-hybrid system by fusing the ligand-binding domain (LBD) of a specific NHR isoforms to the GAL4 DNA-binding domain. This design enables isoform-specific detection of receptor activation based on functional response, allowing for precise, discriminative analysis of nuclear receptor activity

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Receptor Tyrosine Kinase Mutation Cell Line Panels

Signosis offers BaF3 stable cell lines expressing specific mutant tyrosine kinases, including clinically relevant EGFR variants, validated for signaling studies and inhibitor screening. Our cell line panel includes other RTKs mutations such as HER2 and FLT3, as well as the non-receptor Tyrosine Kinase JAK2, expanding utility across multiple oncogenic pathways.

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Parental Cell Lines

Signosis offers some of the parental (Host) cells used for generating stable cell lines. These cell lines can be used as a matched control for their related stable cell lines. All cell lines have been tested negative for mycoplasma.

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Luciferase Substrate

We offer highly sensitive, ready-to-use one-solution substrates for detecting Firefly, Renilla, and Gaussia luciferase. These substrates are extensively validated with our Luciferase Reporter Stable Cell Lines, reporter vectors, and other commercial systems using these luciferases. Designed for ease of use and reliable performance, they support a wide range of gene expression and cellular pathway studies.

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Cell Viability & Proliferation Assays

ATP, XTT, and WST-8 assays are essential tools for measuring cell viability and proliferation in biomedical and pharmaceutical research. These convenient and reliable assays provide researchers with flexible options for evaluating cellular health, cytotoxicity, and the effects of drugs or treatments across a wide range of experimental conditions.

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Products

Target	Name	SKU	Formatted Price
AARE	Amino acid deprivation-AARE Luciferase Reporter HEK293 Stable Cell Line SL-0066	SL-0066	$3,870.00
AARE	Amino acid deprivation-AARE Luciferase Reporter MEF Stable Cell Line SL-0065	SL-0065	$3,870.00
AP-1	AP-1 Luciferase Reporter HEK293 Stable Cell Line SL-0085	SL-0085	$3,870.00
AP-1	AP-1 Luciferase Reporter HeLa Stable Cell Line SL-0019	SL-0019	$2,904.00
AR	AR Luciferase Reporter MDA-MB-453 Stable Cell Line SL-0008	SL-0008	$3,870.00
ATF4	ATF4 Luciferase Reporter HEK293 Stable Cell Line SL-0080	SL-0080	$2,904.00
ATF4	ATF4 Luciferase Reporter HeLa Stable Cell Line SL-0088	SL-0088	$2,904.00
ATF4	ATF4 Luciferase Reporter HepG2 Stable Cell Line SL-0079	SL-0079	$2,904.00
ATF6	ATF6 Luciferase Reporter CHO-K1 Stable Cell Line SL-0024	SL-0024	$2,904.00
ATF6	ATF6 Luciferase Reporter HEK293 Stable Cell Line SL-0084	SL-0084	$3,870.00
ATF6	ATF6 Luciferase Reporter HeLa Stable Cell Line SL-0089	SL-0089	$2,904.00
ATF6	ATF6 Luciferase Reporter HepG2 Stable Cell Line SL-0082	SL-0082	$3,870.00
CHOP	CHOP Luciferase Reporter HEK293 Stable Cell Line SL-0083	SL-0083	$3,870.00
CHOP	CHOP Luciferase Reporter Mia_Paca2 Stable Cell Line SL-0025	SL-0025	$2,904.00
Control	Control HeLa Luciferase Reporter Stable Cell Line SL-0038	SL-0038	$1,165.00
Control	Control HepG2 Luciferase Reporter Stable Cell Line SL-0039	SL-0039	$1,165.00
CREB	CREB Luciferase Reporter HEK293 Stable Cell Line SL-0020	SL-0020	$2,904.00
CREB	CREB Luciferase Reporter NIH/3T3 Stable Cell Line SL-0031	SL-0031	$2,904.00
ELK	ELK Luciferase Reporter HEK293 Stable Cell Line SL-0077	SL-0077	$2,904.00
ELK-TAD	ELK-TAD Luciferase Reporter HEK293 Stable Cell Line SL-0040	SL-0040	$2,904.00
ELK-TAD	ELK-TAD Luciferase Reporter HeLa Stable Cell Line SL-0041	SL-0041	$2,904.00
ER Stress-ERSE	ER Stress-ERSE Luciferase Reporter HEK293 Stable Cell Line SL-0068	SL-0068	$3,870.00
ER Stress-ERSE	ER Stress-ERSE Luciferase Reporter HepG2 Stable Cell Line SL-0069	SL-0069	$3,870.00
ER Stress-ERSE	ER Stress-ERSE Luciferase Reporter MEF Stable Cell Line SL-0067	SL-0067	$3,870.00
ER Stress-ERSE	ER Stress-ERSE Secreted Luciferase Reporter HEK293 Stable Cell Line SL-4068	SL-4068	$3,870.00
Estrogen Receptor	Estrogen Receptor Luciferase Reporter MDA-MB-453 Stable Cell Line SL-0087	SL-0087	$2,904.00
Estrogen Receptor	Estrogen Receptor Luciferase Reporter T47D Stable Cell Line SL-0002	SL-0002	$2,904.00
FXR	FXR Luciferase Reporter HepG2 Stable Cell Line SL-0055	SL-0055	$4,245.00
GAS/Stat1	GAS/Stat1 Luciferase Reporter HCT116 Stable Cell Line SL-0074	SL-0074	$3,870.00
GR	GR Luciferase Reporter HeLa Stable Cell Line SL-0021	SL-0021	$3,870.00
GR	GR Luciferase Reporter MDA-MB-453 Stable Cell Line SL-0009	SL-0009	$3,870.00
HIF	HIF Luciferase Reporter Cos-7 Stable Cell Line SL-0034	SL-0034	$2,904.00
HIF	HIF Luciferase Reporter HeLa Stable Cell Line SL-0023	SL-0023	$2,904.00
HIF	HIF Luciferase Reporter Neuro2a Stable Cell Line SL-0027	SL-0027	$2,904.00
HIF	HIF Luciferase Reporter NIH3T3 Stable Cell Line SL-0005	SL-0005	$2,904.00
IFNa	IFNa Luciferase Reporter HeLa Stable Cell Line SL-0052	SL-0052	$2,904.00
IRF	IRF Luciferase Reporter HEK293 Stable Cell Line SL-0035	SL-0035	$2,904.00
IRF	IRF Luciferase Reporter HepG2 Stable Cell Line SL-0049	SL-0049	$2,904.00
MRF	MRF Luciferase Reporter HEK293 Stable Cell Line SL-0053	SL-0053	$2,904.00
NFAT	NFAT Luciferase Reporter HEK293 Stable Cell Line SL-0078	SL-0078	$2,904.00
NFAT	NFAT Luciferase Reporter HeLa Stable Cell Line SL-0018	SL-0018	$2,904.00
NFAT	NFAT Luciferase Reporter Jurkat Stable Cell Line SL-0032	SL-0032	$2,904.00
NFAT	NFAT Luciferase Reporter NIH 3T3 Stable Cell Line SL-0029	SL-0029	$2,904.00
NFkB	NFkB Luciferase Reporter A549 Stable Cell Line SL-0014	SL-0014	$2,904.00
NFkB	NFkB Luciferase Reporter HEK293 Stable Cell Line SL-0012	SL-0012	$2,904.00
NFkB	NFkB Luciferase Reporter HeLa Stable Cell Line SL-0001	SL-0001	$2,904.00
NFkB	NFkB Luciferase Reporter HepG2 Stable Cell Line SL-0017	SL-0017	$2,904.00
NFkB	NFkB Luciferase Reporter Jurkat Stable Cell Line SL-0050	SL-0050	$3,870.00
NFkB	NFkB Luciferase Reporter MCF7 Stable Cell Line SL-0013	SL-0013	$3,870.00
NFkB	NFkB Luciferase Reporter MDA-MB-231 Stable Cell Line SL-0043	SL-0043	$2,904.00
NFkB	NFkB Luciferase Reporter MEF Stable Cell Line SL-0033	SL-0033	$2,904.00
NFkB	NFkB Luciferase Reporter Neuro2a Stable Cell Line SL-0026	SL-0026	$2,904.00
NFkB	NFkB Luciferase Reporter NIH 3T3 Stable Cell Line SL-0006	SL-0006	$2,904.00
NFkB	NFkB Secreted Luciferase Reporter HEK293 Stable Cell Line SL-4012	SL-4012	$2,904.00
NFkB	NFkB Secreted Luciferase Reporter HeLa Stable Cell Line SL-4001	SL-4001	$2,904.00
NRF2/ARE	NRF2/ARE Luciferase Reporter HEK293 Stable Cell Line SL-0042	SL-0042	$2,904.00
NRF2/ARE	NRF2/ARE Luciferase Reporter HepG2 Stable Cell Line SL-0046	SL-0046	$2,904.00
NRF2/ARE	NRF2/ARE Luciferase Reporter MCF7 Stable Cell Line SL-0010	SL-0010	$2,904.00
NRF2/ARE	NRF2/ARE Luciferase Reporter NIH3T3 Stable Cell Line SL-0047	SL-0047	$2,904.00
NRF2/ARE	NRF2/ARE Secreted Luciferase Reporter HEK293 Stable Cell Line SL-4042	SL-4042	$2,904.00
p53	p53 Luciferase Reporter HCT116 Stable Cell Line SL-0072	SL-0072	$3,870.00
p53	p53 Luciferase Reporter HeLa Stable Cell Line SL-0011	SL-0011	$3,870.00
p53	p53 Luciferase Reporter RKO Stable Cell Line SL-0007	SL-0007	$3,870.00
RAR	RAR Luciferase Reporter HEK293 Stable Cell Line SL-0086	SL-0086	$3,870.00
SMAD/BMP	SMAD/BMP Responsive Luciferase Reporter HEK293 Stable Cell Line SL-0051	SL-0051	$3,870.00
SMAD/BMP	SMAD/BMP Responsive Luciferase Reporter HepG2 Stable Cell Line SL-0090	SL-0090	$3,870.00
SMAD/BMP	SMAD/BMP Secreted Responsive Luciferase Reporter HEK293 Stable Cell Line SL-4051	SL-4051	$3,870.00
SMAD/TGFbeta	SMAD/TGFbeta Luciferase Reporter HepG2 Stable Cell Line SL-0016	SL-0016	$3,870.00
SMAD/TGFbeta	SMAD/TGFbeta Luciferase Reporter NIH/3T3 Stable Cell Line SL-0030	SL-0030	$2,904.00
Stat1	Stat1 Luciferase Reporter HeLa Stable Cell Line SL-0004	SL-0004	$2,904.00
Stat3	Stat3 Luciferase Reporter HEK293 Stable Cell Line SL-0071	SL-0071	$3,870.00
Stat3	Stat3 Luciferase Reporter HepG2 Stable Cell Line SL-0081	SL-0081	$3,870.00
TCF/LEF	TCF/LEF Luciferase Reporter CHO-K1 Stable Cell Line SL-0028	SL-0028	$2,904.00
TCF/LEF	TCF/LEF Luciferase Reporter HEK293 Stable Cell Line SL-0015	SL-0015	$3,870.00
TCF/LEF	TCF/LEF Luciferase Reporter HeLa Stable Cell Line SL-0022	SL-0022	$2,904.00
XRE	XRE Luciferase Reporter HEK293 Stable Cell Line SL-0075	SL-0075	$2,904.00